α-diphenyl(methyl)silyl-4-methylvaleric acid | 1269601-06-0

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: α-diphenyl(methyl)silyl-4-methylvaleric acid
• 英文别名: 4-Methyl-2-[methyl(diphenyl)silyl]pentanoic acid；4-methyl-2-[methyl(diphenyl)silyl]pentanoic acid
• CAS: 1269601-06-0
• 化学式: C₁₉H₂₄O₂Si
• 分子量: 312.484
• InChiKey: BRAVRDMZNQSINU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.38
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲基二苯基氯硅烷 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 3.92h， 生成 α-diphenyl(methyl)silyl-4-methylvaleric acid
  参考文献：
  名称：

  Synthesis of α-silylcarboxylic acids

  摘要：

  New alpha-silylacetic acids have been prepared following a general and convenient procedure of a one-pot reaction between trimethylsilylacetate and different chlorosilanes. New derivatives of diphenyl(methyl) silylacetic acid were prepared by a direct alkylation of its dianion with benzyl-, allyl-, and alkyl halides and trimethylchlorogermane to afford new alpha-silylcarboxylic acids. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.12.020

文献信息

• Synthesis of α-silylcarboxylic acids
  作者：Alex V. Shtelman、James Y. Becker

  DOI：10.1016/j.tet.2010.12.020

  日期：2011.2

  New alpha-silylacetic acids have been prepared following a general and convenient procedure of a one-pot reaction between trimethylsilylacetate and different chlorosilanes. New derivatives of diphenyl(methyl) silylacetic acid were prepared by a direct alkylation of its dianion with benzyl-, allyl-, and alkyl halides and trimethylchlorogermane to afford new alpha-silylcarboxylic acids. (C) 2010 Elsevier Ltd. All rights reserved.