(E)-4-phenyl-2-(3-(thiophen-2-yl)acrylamido)thiophene-3-carboxylic acid | 1815599-41-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: (E)-4-phenyl-2-(3-(thiophen-2-yl)acrylamido)thiophene-3-carboxylic acid
• 英文别名: 4-phenyl-2-[[(E)-3-thiophen-2-ylprop-2-enoyl]amino]thiophene-3-carboxylic acid
• CAS: 1815599-41-7
• 化学式: C₁₈H₁₃NO₃S₂
• 分子量: 355.4
• InChiKey: BTURFDFZCYITAI-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING O-GLYCOSYLATION
  申请人：Gross Benjamin

  公开号：US20100290987A1

  公开（公告）日：2010-11-18

  The invention relates to methods and products for modulating glycosylation of proteins. The invention is useful for identifying therapeutic compounds to treat glycosylation-associated disorders such as neurodegeneration, diabetes, including complications of diabetes such as insulin resistance, nephropathy, microvascular damage, and endothelial dysfunction. The invention is also useful for identifying therapeutic compounds to treat de-glycosylation-associated disorders such as ischemic damage and traumatic injury. The invention also relates in part to assays that are useful for identifying and testing candidate compounds for modulating glycosylation of proteins and also relates in part to compounds to treat glycosylation-associated diseases and disorders.
• TARGETING PHOSPHOFRUCTOKINASE AND ITS GLYCOSYLATION FORM FOR CANCER
  申请人：California Institute of Technology

  公开号：US20150369809A1

  公开（公告）日：2015-12-24

  The present invention relates to methods of treating cancer, suppressing or inhibiting tumorigenesis, tumor growth or cancer progression, and suppressing or inhibiting cancer cells from altering cellular metabolism in favor of cancerous growth. Also provided are compositions comprising an agent that decreases glycosylation of phosphofructokinase 1 or increases phosphofructokinase 1 expression or activity.
• US8524444B2
  申请人：——

  公开号：US8524444B2

  公开（公告）日：2013-09-03
• US8993718B2
  申请人：——

  公开号：US8993718B2

  公开（公告）日：2015-03-31
• US9645151B2
  申请人：——

  公开号：US9645151B2

  公开（公告）日：2017-05-09