N-(1-benzylpiperidin-4-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(1-benzylpiperidin-4-yl)-5,6-dimethylthieno[2,3-d]pyrimidin-4-amine
• 化学式: C₂₀H₂₄N₄S
• 分子量: 352.5
• InChiKey: CGRZMNFYFYJXES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  69.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA<br/>[FR] COMPOSITIONS ET MÉTHODES DE TRAITEMENT DE LA LEUCÉMIE
  申请人：UNIV MICHIGAN

  公开号：WO2011029054A1

  公开（公告）日：2011-03-10

  The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.

  本发明涉及有效治疗白血病的方法。具体而言，本发明提供了抑制Menin与MLL和MLL融合癌基因蛋白相互作用的组合物和方法，以及筛选这些组合物的系统和方法。
• COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA
  申请人：The Regents of the University of Michigan

  公开号：EP2473054B1

  公开（公告）日：2017-06-14
• INHIBITORS OF CYCLIC AMP PHOSPHODIESTERASES
  申请人：Hoffman Charles S.

  公开号：US20100227853A1

  公开（公告）日：2010-09-09

  Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical and biological inhibitors or activators of a target exogenous phosphodiesterase (PDE). The invention provides, in some aspects, compounds that inhibit cAMP PDE activity and compositions that include such compounds. The invention, in part, also includes methods of using cAMP PDE-inhibiting compounds in the treatment of cAMP PDE-associated diseases and/or disorders.
• US8993552B2
  申请人：——

  公开号：US8993552B2

  公开（公告）日：2015-03-31