2-[[2-(3,5-Dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-4,5-dimethylthiophene-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 2-[[2-(3,5-Dimethyl-4-nitropyrazol-1-yl)acetyl]amino]-4,5-dimethylthiophene-3-carboxamide
• 化学式: C14H17N5O4S
• mdl: MFCD01243774
• 分子量: 351.38
• InChiKey: BYHHTSWBLHUHQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  164
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• 11Beta -Hydroxysteroid Dehydrogenases
  申请人：Wilckens Thomas

  公开号：US20080153791A1

  公开（公告）日：2008-06-26

  The present invention relates to novel 11β-HSD inhibitors as well as to the use of 11 β-HSD inhibitors for the manufacture of pharmaceutical agents for the prevention and/or treatment of metabolic diseases, cancer, cell proliferation, glaucoma, diseases associated with abnormal growth hormone secretion as well as wound healing disorders.
• Prevention and treatment of inflammation-induced and/or immune-mediated bone loss
  申请人：Wilckens Thomas

  公开号：US20100087413A1

  公开（公告）日：2010-04-08

  The present invention relates to the use of an 11-β-HSD-type 1 and or type 2 inhibitor for the manufacture of a pharmaceutical agent for the prevention and/or treatment of inflammation-induced and/or immune-mediated loss of bone and/or cartilage.
• PREVENTION AND TREATMENT OF INFLAMMATION-INDUCED AND/OR IMMUNE-MEDIATED BONE LOSS
  申请人：WILCKENS Thomas

  公开号：US20110275584A1

  公开（公告）日：2011-11-10

  The present invention relates to the use of an 11-β-HSD-type 1 and/or type 2 inhibitor for the manufacture of a pharmaceutical agent for the prevention and/or treatment of inflammation-induced and/or immune-mediated loss of bone and/or cartilage.