[(2S)-2,3-dihydroxypropyl] 5-[3-[(1R,2R,5S)-2-chloro-5-[2-(3,5-dichlorophenyl)ethyl]cyclopentyl]propyl]thiophene-2-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: [(2S)-2,3-dihydroxypropyl] 5-[3-[(1R,2R,5S)-2-chloro-5-[2-(3,5-dichlorophenyl)ethyl]cyclopentyl]propyl]thiophene-2-carboxylate
• 化学式: C₂₄H₂₉Cl₃O₄S
• 分子量: 519.9
• InChiKey: KASSVLHMZHMYTP-NTSGDEEZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  95
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] REDUCED CENTRAL CORNEAL THICKENING BY USE OF HYDROPHILIC ESTER PRODRUGS OF BETA-CHLOROCYCLOPENTANES<br/>[FR] ÉPAISSISSEMENT RÉDUIT DE LA CORNÉE CENTRALE À L'AIDE DE PROMÉDICAMENTS ESTERS HYDROPHILES DE BÊTA-CHLOROCYCLOPENTANES
  申请人：ALLERGAN INC

  公开号：WO2014035827A1

  公开（公告）日：2014-03-06

  Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs of formula (I) and formula (III) and said compounds for use to reduce central corneal thickening is provided, wherein L1 -L3, R1 and R2 are as defined in claim 1 and n and R2D as defined in claim 37. Formula (I), Formula (III).
• [EN] REDUCED CENTRAL CORNEAL THICKENING BY USE OF HYDROPHILIC ESTER PRODRUGS OF BETA-CHLOROCYCLOPENTANES<br/>[FR] RÉDUCTION DE L'ÉPAISSISSEMENT CORNÉEN CENTRAL PAR UTILISATION DE PROMÉDICAMENTS D'ESTERS HYDROPHILES DE BÊTA-CHLOROCYCLOPENTANES
  申请人：ALLERGAN INC

  公开号：WO2015175075A1

  公开（公告）日：2015-11-19

  Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs of the below-mentioned formula and their use to reduce central corneal thickening is provided. (I)