[(3R,7S,8S)-8-[(3S,5R)-7-[[1-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl]piperidin-4-yl]amino]-3,5-dihydroxy-7-oxoheptyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [(3R,7S,8S)-8-[(3S,5R)-7-[[1-[(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl]piperidin-4-yl]amino]-3,5-dihydroxy-7-oxoheptyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate
• 化学式: C₅₂H₈₀N₂O₆
• 分子量: 829.2
• InChiKey: WRBBCPOQMSPMBJ-REBHOCRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  60
• 可旋转键数：
  26
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  116
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] FATTY ACID CONJUGATES OF STATIN AND FXR AGONISTS; COMPOSITIONS AND METHOD OF USES<br/>[FR] CONJUGUÉS D'ACIDE GRAS DE STATINE ET D'AGONISTES DE FXR ; COMPOSITIONS ET PROCÉDÉS D'UTILISATION
  申请人：CATABASIS PHARMACEUTICALS INC

  公开号：WO2013166176A1

  公开（公告）日：2013-11-07

  The invention relates to fatty acid statin conjugates and fatty acid FXR agonist conjugates; compositions comprising an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate.

  该发明涉及脂肪酸他汀共轭物和脂肪酸FXR激动剂共轭物；包含有效量脂肪酸他汀共轭物或脂肪酸FXR激动剂共轭物的组合物；以及治疗或预防代谢性疾病的方法，包括给予有效量脂肪酸他汀共轭物或脂肪酸FXR激动剂共轭物。
• FATTY ACID CONJUGATES OF STATIN AND FXR AGONISTS: COMPOSITIONS AND METHODS OF USE
  申请人：Catabasis Pharmaceuticals, Inc.

  公开号：US20160015819A1

  公开（公告）日：2016-01-21

  The invention relates to fatty acid statin conjugates and fatty acid FXR agonist conjugates; compositions comprising an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate; and methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid statin conjugate or a fatty acid FXR agonist conjugate.

  本发明涉及脂肪酸他汀共轭物和脂肪酸FXR激动剂共轭物；包含有效量脂肪酸他汀共轭物或脂肪酸FXR激动剂共轭物的组合物；以及治疗或预防代谢性疾病的方法，包括给予有效量脂肪酸他汀共轭物或脂肪酸FXR激动剂共轭物。
• FATTY ACID CONJUGATES OF STATIN AND FXR AGONISTS; COMPOSITIONS AND METHOD OF USES
  申请人：Catabasis Pharmaceuticals, Inc.

  公开号：EP2844257A1

  公开（公告）日：2015-03-11
• US9084826B2
  申请人：——

  公开号：US9084826B2

  公开（公告）日：2015-07-21