1-Ethylsulfinyl-5-isothiocyanatopentane

• 分子结构分类: 有机化合物 - 有机硫化合物 - 亚砜
• 英文名称: 1-Ethylsulfinyl-5-isothiocyanatopentane
• 英文别名: 1-ethylsulfinyl-5-isothiocyanatopentane
• 化学式: C₈H₁₅NOS₂
• 分子量: 205.3
• InChiKey: BTTQRCJQMGUWNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  80.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] MELANOMA CHEMOPREVENTION<br/>[FR] CHIMIO-PRÉVENTION DU MÉLANOME
  申请人：UNIV PITTSBURGH

  公开号：WO2013166421A1

  公开（公告）日：2013-11-07

  Disclosed herein are methods and uses for preventing melanoma, reducing progression of atypical nevi, and inducing cell cycle arrest and/or apoptosis in a melanoma cell through oral and enteral administration of sulforaphane to subjects indicated to be at risk due to factor(s) such as medical history of atypical nevi, melanoma, or UV exposure. Sulforaphane can be administered orally as a safe and well-tolerated natural agent as a chemopreventive strategy in individuals with atypical melanocytic nevi.