4,5-Dehydro Apixaban

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4,5-Dehydro Apixaban
• 英文别名: 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]pyrazolo[3,4-c]pyridine-3-carboxamide
• 化学式: C₂₅H₂₃N₅O₄
• 分子量: 457.5
• InChiKey: CBTJDWJXHOSJHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Novel intermediate and polymorphs of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetra hydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide and process thereof
  申请人：THIRUMALAI RAJAN Srinivasan

  公开号：US20150353541A1

  公开（公告）日：2015-12-10

  The present invention provides a novel intermediate as well as novel polymorphs of 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide compound represented by the following structural formula-1 and processes for their preparation.

  本发明提供了一种新的中间体以及新的多形态结构的1-(4-甲氧基苯基)-7-氧代-6-[4-(2-氧代哌啶-1-基)苯基]-4,5,6,7-四氢-1H-吡唑并[3,4-c]吡啶-3-羧酰胺化合物，其化学结构如下所示，并提供了其制备方法。
• US9718779B2
  申请人：——

  公开号：US9718779B2

  公开（公告）日：2017-08-01
• [EN] AMORPHOUS FORM OF APIXABAN, PROCESS OF PREPARATION AND COMPOSITIONS THEREOF<br/>[FR] FORME AMORPHE D'APIXABAN, SON PROCÉDÉ DE PRÉPARATION ET COMPOSITIONS DE CELLE-CI
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2013164839A2

  公开（公告）日：2013-11-07

  The present invention discloses an amorphous form of apixaban, process of preparation and compositions thereof.
• [EN] NOVEL INTERMEDIATE AND POLYMORPHS OF 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL)PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-c] PYRIDINE-3-CARBOXAMIDE AND PROCESS THEREOF<br/>[FR] NOUVEL INTERMÉDIAIRE ET NOUVEAUX POLYMORPHES DU 1-(4-MÉTHOXYPHÉNYL)-7-OXO-6-[4-(2-OXOPIPÉRIDIN-1-YL)PHÉNYL]-4,5,6,7-TÉTRAHYDRO-1H-PYRAZOLO[3,4-C]PYRIDINE-3-CARBOXAMIDE ET PROCÉDÉ S'Y RAPPORTANT
  申请人：MSN LAB LTD

  公开号：WO2014108919A2

  公开（公告）日：2014-07-17

  THE PRESENT INVENTION PROVIDES NOVEL INTERMEDIATE AND NOVEL POLYMORPHS OF 1-(4-METHOXYPHENYL)-7-OXO-6-[4-(2-OXOPIPERIDIN-1-YL) PHENYL]-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[3,4-c]PYRIDINE-3-CARBOXAMIDE AND PROCESSES FOR THEIR PREPARATION