(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;2-ethoxy-4-[2-[[(1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butyl]amino]-2-oxoethyl]benzoic acid
• 化学式: C44H62N4O5
• 分子量: 727.0
• InChiKey: WQFZJRIOXHZEOU-XTSYIHLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.73
• 重原子数：
  53
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  111
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• DEPOT FORMULATIONS OF A HYDROPHOBIC ACTIVE INGREDIENT AND METHODS FOR PREPARATION THEREOF
  申请人：Painreform Ltd.

  公开号：EP2846772A1

  公开（公告）日：2015-03-18
• Depot Formulations of a Hydrophobic Active Ingredient and Methods for Preparation Thereof
  申请人：PAINREFORM LTD.

  公开号：US20150148325A1

  公开（公告）日：2015-05-28

  The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a hydrophobic active pharmaceutical ingredient (API) of low water solubility but readily dissolved in alcohols and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.
• US9849088B2
  申请人：——

  公开号：US9849088B2

  公开（公告）日：2017-12-26
• [EN] DEPOT FORMULATIONS OF A HYDROPHOBIC ACTIVE INGREDIENT AND METHODS FOR PREPARATION THEREOF<br/>[FR] PRÉPARATIONS DE DÉPÔT D'UN PRINCIPE ACTIF HYDROPHOBE ET PROCÉDÉS DE PRÉPARATION ASSOCIÉS
  申请人：PAINREFORM LTD

  公开号：WO2013168167A1

  公开（公告）日：2013-11-14

  The invention provides extended release pro-liposomal, non-aqueous, pharmaceutical formulations of a hydrophobic active pharmaceutical ingredient (API) of low water solubility but readily dissolved in alcohols and methods for making same. The formulations can be administered by infiltration into an incision, or by injection.