4-Fluoro-1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-Fluoro-1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid
• 英文别名: 4-fluoro-1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid
• 化学式: C₇H₁₀FNO₃
• 分子量: 175.16
• InChiKey: KBXRDMIEACRADY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  53.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] FATTY ACID SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS DE L'ACIDE GRAS SYNTHASE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2013177253A2

  公开（公告）日：2013-11-28

  Disclosed are compounds having Formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, Y, m, and n are defined herein and methods of using the same.
• [EN] FATTY ACID SYNTHASE INHIBITORS<br/>[FR] INHIBITEURS D'ACIDE GRAS SYNTHASE
  申请人：GLAXOSMITHKLINE LLC

  公开号：WO2014008223A2

  公开（公告）日：2014-01-09

  This invention relates to novel spirocyclic piperidines according to Formula (I) which are inhibitors of fatty acid synthase (FAS), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of cancers.