[1-(2,4-Diaminophenyl)piperidin-4-yl]-trimethylazanium

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: [1-(2,4-Diaminophenyl)piperidin-4-yl]-trimethylazanium
• 英文别名: [1-(2,4-diaminophenyl)piperidin-4-yl]-trimethylazanium
• 化学式: C14H25N4+
• 分子量: 249.38
• InChiKey: XUQRYVFKCFZQNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  55.3
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] DYE COMPOSITION COMPRISING A CATIONIC META-PHENYLENEDIAMINE<br/>[FR] COMPOSITION DE COLORANT COMPRENANT UNE MÉTA-PHÉNYLÈNEDIAMINE CATIONIQUE
  申请人：OREAL

  公开号：WO2014005900A1

  公开（公告）日：2014-01-09

  One subject of the invention is a meia-phenylenediamine compound having formula (I) below, the addition salts thereof with an acid and the solvates thereof: in which: • R represents a hydrogen or halogen atom; a C1-C4 alkyl group; a carboxyl group or a (C1-C4)alkoxycarbonyl group, • R1 represents a C1-C10(hydroxy)alkyl group, optionally interrupted with one or more non-adjacent oxygen atoms or non-adjacent NR' substituents, substituted by a cationic CAT group, • R2 represents a hydrogen atom or a C1-C4(hydroxy)alkyl group, • R1 and R2 may form, together with the atom that bears them, a cationic heterocycle with 5 to 8 members, • R' represents a hydrogen atom or a C1-C4(hydroxy)alkyl group; • An" represents an anion or a mixture of anions which are organic or inorganic and cosmetically acceptable.

  本发明的一个主题是具有以下公式（I）的介苯二胺化合物及其与酸的加成盐和溶剂化物：其中： • R代表氢或卤素原子；C1-C4烷基；羧基或（C1-C4）烷氧羰基基团， • R1代表C1-C10（羟基）烷基，可选地中断一个或多个非相邻氧原子或非相邻NR'取代基，被带正电荷的CAT基团取代， • R2代表氢原子或C1-C4（羟基）烷基， • R1和R2可以与承载它们的原子一起形成具有5到8个成员的带正电荷的杂环， • R'代表氢原子或C1-C4（羟基）烷基； • An"代表有机或无机的、在化妆品中可接受的阴离子或阴离子混合物。
• DYE COMPOSITION COMPRISING A CATIONIC META-PHENYLENEDIAMINE
  申请人：L'Oréal

  公开号：EP2867212A1

  公开（公告）日：2015-05-06
• ABUSE DETERRENT PHARMACEUTICAL COMPOSITIONS FOR CONTROLLED RELEASE
  申请人：Egalet Ltd.

  公开号：EP2877161A1

  公开（公告）日：2015-06-03
• US9345653B2
  申请人：——

  公开号：US9345653B2

  公开（公告）日：2016-05-24
• [EN] ABUSE DETERRENT PHARMACEUTICAL COMPOSITIONS FOR CONTROLLED RELEASE<br/>[FR] COMPOSITIONS PHARMACEUTIQUES DE DISSUASION D'ABUS À LIBÉRATION CONTRÔLÉE
  申请人：EGALET LTD

  公开号：WO2014006004A1

  公开（公告）日：2014-01-09

  The present invention relates to pharmaceutical compositions that are abuse resistant and may also provide controlled release. The present invention also relates to the use of said pharmaceutical compositions in the treatment of pain.