2-Bromoethanol;2-piperidin-1-ylethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-Bromoethanol;2-piperidin-1-ylethanol
• 英文别名: 2-bromoethanol;2-piperidin-1-ylethanol
• 化学式: C9H20BrNO2
• 分子量: 254.16
• InChiKey: MFZWNFRRHAPSQZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.84
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• BITOPIC MUSCARINIC AGONISTS AND ANTAGONISTS AND METHODS OF SYNTHESIS AND USE THEREOF
  申请人：BARRY UNIVERSITY, INC.

  公开号：US20160136145A1

  公开（公告）日：2016-05-19

  Compositions for treating a condition associated with activity of a muscarinic receptor (e.g., one or more of M 1 , M 2 , M 3 , M 4 , M 5 ) and for anesthetizing a subject include a bitopic muscarinic antagonist or agonist. A bitopic muscarinic antagonist named JB-D4 was discovered. Additional bitopic muscarinic antagonists discovered and described herein include BK-23, HD-42, HD153, HD-185, KH-5, JM-31 and JM-32. These bitopic ligands and their structural analogs, as well as bitopic muscarinic agonists, may be used as neuromuscular blocking agents (e.g., for use in compositions for anesthetizing a subject) and for the treatment of central nervous system disorders (e.g., Parkinson's disease, Schizophrenia, etc.), Overactive Bladder Syndrome, Chronic Obstructive Pulmonary Disease, asthma, and many other diseases associated with the activation or inhibition of M 1 -M 5 acetylcholine receptors.

  用于治疗与肌肉乙酰胆碱受体活性有关的疾病（例如M1、M2、M3、M4、M5中的一个或多个）和麻醉受试者的组合物包括一个双位点肌肉乙酰胆碱受体拮抗剂或激动剂。一种双位点肌肉乙酰胆碱受体拮抗剂命名为JB-D4已被发现。此外，还发现并描述了其他双位点肌肉乙酰胆碱受体拮抗剂，包括BK-23、HD-42、HD153、HD-185、KH-5、JM-31和JM-32。这些双位点配体及其结构类似物，以及双位点肌肉乙酰胆碱受体激动剂，可用作神经肌肉阻滞剂（例如用于麻醉受试者的组合物）以及用于治疗中枢神经系统疾病（例如帕金森病、精神分裂症等）、过度活动性膀胱综合症、慢性阻塞性肺疾病、哮喘和许多与M1-M5乙酰胆碱受体的激活或抑制有关的疾病。
• US9662318B2
  申请人：——

  公开号：US9662318B2

  公开（公告）日：2017-05-30
• [EN] BITOPIC MUSCARINIC AGONISTS AND ANTAGONISTS AND METHODS OF SYNTHESIS AND USE THEREOF<br/>[FR] AGONISTES ET ANTAGONISTES MUSCARINIQUES BITOPIQUES ET PROCÉDÉS DE SYNTHÈSE ET D'UTILISATION ASSOCIÉS
  申请人：BARRY UNIVERSITY INC

  公开号：WO2014014698A2

  公开（公告）日：2014-01-23

  Compositions for treating a condition associated with activity of a muscarinic receptor (e.g., one or more of M1, M2, M3, M4, M5) and for anesthetizing a subject include a bitopic muscarinic antagonist or agonist. A bitopic muscarinic antagonist named JB-D4 was discovered. This bitopic ligand and its structural analogs, as well as bitopic muscarinic agonists, may be used as neuromuscular blocking agents (e.g., for use in compositions for anesthetizing a subject) and for the treatment of central nervous system disorders (e.g., Parkinson's disease, Schizophrenia, etc.), Overactive Bladder Syndrome, Chronic Obstructive Pulmonary Disease, asthma, and many other diseases associated with the activation or inhibition of M1-M5 acetylcholine receptors.