2,2-Bis[4-(dimethylamino)phenyl]-2-[4-(2-hydroxyethoxy)phenyl]acetonitrile | 934347-16-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 三苯基化合物
• 英文名称: 2,2-Bis[4-(dimethylamino)phenyl]-2-[4-(2-hydroxyethoxy)phenyl]acetonitrile
• 英文别名: 2,2-bis[4-(dimethylamino)phenyl]-2-[4-(2-hydroxyethoxy)phenyl]acetonitrile
• CAS: 934347-16-7
• 化学式: C₂₆H₂₉N₃O₂
• 分子量: 415.535
• InChiKey: UNPDESNMWOZMKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  59.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-溴-1-丙烷磺酸 、 2,2-Bis[4-(dimethylamino)phenyl]-2-[4-(2-hydroxyethoxy)phenyl]acetonitrile 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 14.0h， 以68%的产率得到3-(2-(4-(cyanobis(4-(dimethylamino)phenyl)methyl)phenoxy)ethoxy)propane-1-sulfonic acid
  参考文献：
  名称：

  UV-Responsive Polymeric Superamphiphile Based on a Complex of Malachite Green Derivative and a Double Hydrophilic Block Copolymer

  摘要：

  We have prepared a UV-responsive polymeric super-amphiphile, formed by a malachite green derivative and the double hydrophilic block copolymer methoxy-poly(ethylene glycol)(114)-block-poly(L-lysine hydrochloride)(200) (PEG-b-PLKC) on the basis of electrostatic interactions. The malachite green derivative undergoes photo-ionization upon UV irradiation, which makes it more hydrophilic, resulting in changes in the self-assembly behavior of the polymeric superamphiphile. For this reason, the polymeric superamphiphile originally self-assembles to form sheetlike aggregates, which disassemble after UV irradiation because of the increased solubility of the malachite green derivative. By use of Nile red as a probe, the polarity of the polymeric superamphiphile solution is confirmed to be increased after UV irradiation by fluorescence spectra, which also explains the disassembly of the polymeric superamphiphile.

  DOI：

  10.1021/la203486q
• 作为产物：
  描述：

  在 alkaline phosphatase 作用下， 以 aq. buffer 为溶剂， 反应 0.25h， 生成 2,2-Bis[4-(dimethylamino)phenyl]-2-[4-(2-hydroxyethoxy)phenyl]acetonitrile
  参考文献：
  名称：

  Detecting targets using mass tags and mass spectrometry

  摘要：

  本文披露的特定实施例涉及使用一个或多个不同质量标记，可以通过直接或间接的酶催化转化在靶标上特异地沉积，提供一种用于识别组织样本中的靶标的方法。质量标记可以用稳定同位素标记，以产生具有相同化学结构但质量不同的质量标记。通过对质量标记进行电离产生的质量编码通过质谱检测和/或定量。该方法可用于在特定样本中多重检测多个靶标。在一些实施例中，可以准备一个被划分为代表组织样本部分的部分的地图，其中地图部分包括对应于定量数据的数据，其中质量峰的大小被确定并与相应组织样本部分的靶标数量相关联。

  公开号：

  US09291597B2

文献信息

• DETECTING TARGETS USING MASS TAGS AND MASS SPECTROMETRY
  申请人：Ventana Medical Systems, Inc.

  公开号：EP2588144B1

  公开（公告）日：2018-05-09
• US9291597B2
  申请人：——

  公开号：US9291597B2

  公开（公告）日：2016-03-22
• Detecting targets using mass tags and mass spectrometry
  申请人：Hong Rui

  公开号：US09291597B2

  公开（公告）日：2016-03-22

  Particular disclosed embodiments disclosed herein concern using a one or more various mass tags, which can be specifically deposited at targets through direct or indirect enzymatic-catalyzed transformation, to provide a method for identifying targets in tissue samples. The mass tags may be labeled with stable isotopes to produce mass tags having the same chemical structure but different masses. Mass codes produced by ionizing the mass tags are detected and/or quantified using mass spectrometry. The method can be used for multiplexed detection of multiple targets in a particular sample. In some embodiments, a map divided into sections representing sections of the tissue sample may be prepared, with the map sections including data corresponding to quantification data wherein the size of a mass peak is determined and correlated with the amount of a target for the corresponding tissue sample section.

  本文披露的特定实施例涉及使用一个或多个不同质量标记，可以通过直接或间接的酶催化转化在靶标上特异地沉积，提供一种用于识别组织样本中的靶标的方法。质量标记可以用稳定同位素标记，以产生具有相同化学结构但质量不同的质量标记。通过对质量标记进行电离产生的质量编码通过质谱检测和/或定量。该方法可用于在特定样本中多重检测多个靶标。在一些实施例中，可以准备一个被划分为代表组织样本部分的部分的地图，其中地图部分包括对应于定量数据的数据，其中质量峰的大小被确定并与相应组织样本部分的靶标数量相关联。
• UV-Responsive Polymeric Superamphiphile Based on a Complex of Malachite Green Derivative and a Double Hydrophilic Block Copolymer
  作者：Peng Han、Sichao Li、Chao Wang、Huaping Xu、Zhiqiang Wang、Xi Zhang、Joice Thomas、Mario Smet

  DOI：10.1021/la203486q

  日期：2011.12.6

  We have prepared a UV-responsive polymeric super-amphiphile, formed by a malachite green derivative and the double hydrophilic block copolymer methoxy-poly(ethylene glycol)(114)-block-poly(L-lysine hydrochloride)(200) (PEG-b-PLKC) on the basis of electrostatic interactions. The malachite green derivative undergoes photo-ionization upon UV irradiation, which makes it more hydrophilic, resulting in changes in the self-assembly behavior of the polymeric superamphiphile. For this reason, the polymeric superamphiphile originally self-assembles to form sheetlike aggregates, which disassemble after UV irradiation because of the increased solubility of the malachite green derivative. By use of Nile red as a probe, the polarity of the polymeric superamphiphile solution is confirmed to be increased after UV irradiation by fluorescence spectra, which also explains the disassembly of the polymeric superamphiphile.