(8S,14S,20S,22R,31R,34R)-11,14,16,20,22,25,28,34-octamethyl-10,35-dioxa-4-azatricyclo[29.3.1.04,8]pentatriacontane-3,9-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酯内酰胺
• 英文名称: (8S,14S,20S,22R,31R,34R)-11,14,16,20,22,25,28,34-octamethyl-10,35-dioxa-4-azatricyclo[29.3.1.04,8]pentatriacontane-3,9-dione
• 化学式: C₄₀H₇₃NO₄
• 分子量: 632.0
• InChiKey: JOZBIHULNUFUQS-WVYRZUGBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.6
• 重原子数：
  45
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• MODIFIABLE CHEMICAL INDUCERS OF PROXIMITY AND METHODS OF USING THE SAME
  申请人：Clontech Laboratories, Inc.

  公开号：US20140080137A1

  公开（公告）日：2014-03-20

  Methods of reversibly inducing proximity of first and second target molecules in a sample are provided. Aspects of the methods include contacting the sample with a modifiable chemical inducer of proximity (MCIP) that reversibly induces proximity of the first and second target molecules, upon application of a stimulus that modifies the MCIP. Aspects of the invention further include methods for regulating a biological process in a cell. Aspects of the invention further include compositions, e.g., compounds and kits, etc., that find use in methods of the invention.