Tert-butyl 4-(2-ethoxycarbonyloxyacetyl)oxypiperidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Tert-butyl 4-(2-ethoxycarbonyloxyacetyl)oxypiperidine-1-carboxylate
• 英文别名: tert-butyl 4-(2-ethoxycarbonyloxyacetyl)oxypiperidine-1-carboxylate
• 化学式: C₁₅H₂₅NO₇
• 分子量: 331.36
• InChiKey: DROZFYLOEFVDGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  91.4
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] POLYCARBONATES BEARING PENDANT PRIMARY AMINES FOR MEDICAL APPLICATIONS<br/>[FR] POLYCARBONATES PORTANT DES AMINES PRIMAIRES LATÉRALES POUR DES APPLICATIONS MÉDICALES
  申请人：IBM

  公开号：WO2014042924A1

  公开（公告）日：2014-03-20

  An antimicrobial composition comprises an anionic drug and an amine polymer comprising a first repeat unit of formula (2); wherein a' is an integer equal to 1 or 2, b' is an integer equal to 1 or 2, and each R' is an independent monovalent radical selected from the group consisting of hydrogen, methyl, ethyl, and combinations thereof. G' is a divalent linking group selected from the group consisting of a single bond and groups comprising at least one carbon. X¯ is a negatively charged counterion. The drug and the amine polymer are bound by noncovalent interactions.

  一种抗微生物组合物包括一种阴离子药物和一种胺聚合物，该胺聚合物包括公式（2）的第一重复单元；其中a'是等于1或2的整数，b'是等于1或2的整数，每个R'是从氢、甲基、乙基和它们的组合中选取的独立一价基团。G'是从单键和至少含有一个碳的基团中选取的二价连接基团。X¯是带负电的对离子。药物和胺聚合物通过非共价相互作用结合。
• [EN] ANTIMICROBIAL GUANIDINIUM AND THIOURONIUM FUNCTIONALIZED POLYMERS<br/>[FR] POLYMÈRES FONCTIONNALISÉS PAR GUANIDINIUM ET THIOURONIUM ANTIMICROBIENS
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2016186581A1

  公开（公告）日：2016-11-24

  Antimicrobial cationic polycarbonates and polyurethanes have been prepared comprising one or more pendent guanidinium and/or isothiouronium groups. Additionally, antimicrobial particles were prepared having a silica core linked to surface groups comprising a guanidinium and/or isothiouronium group. The cationic polymers and cationic particles can be potent antimicrobial agents against Gram-negative microbes, Gram-positive microbes, and/or fungi.

  已制备含有一个或多个侧链胍啉和/或异硫脲基团的抗菌阳离子聚碳酸酯和聚氨酯。此外，制备了含有硅核心的抗菌颗粒，其与表面基团相连，包括一个胍啉和/或异硫脲基团。这些阳离子聚合物和阳离子颗粒可以是对革兰氏阴性微生物、革兰氏阳性微生物和/或真菌具有强效抗菌作用的剂。
• [EN] COMPOSITE HYDROGELS FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS<br/>[FR] HYDROGELS COMPOSITES POUR L'ADMINISTRATION DE MATIÈRES BIOLOGIQUEMENT ACTIVES
  申请人：IBM

  公开号：WO2014042921A1

  公开（公告）日：2014-03-20

  A composite hydrogel comprises an amphiphilic triblock copolymer (ABA) and a loaded micelle bound by noncovalent interactions. The loaded micelle comprises a biologically active substance and an amphiphilic diblock copolymer (CD). The A blocks comprise a steroidal repeat unit (repeat unit 1) having both a backbone carbonate and a side chain bearing a steroid functional group. Each of the A blocks has a degree of polymerization of about 0.5 to about 4.0. The B block comprises a first poly(alkylene oxide) backbone. The C block comprises a second poly(alkylene oxide) backbone. The D block comprises a steroidal repeat unit (repeat unit 2) having both a backbone carbonate group and a side chain comprising a steroid functional group. The composite hydrogel is capable of controlled release of the biologically active substance.

  一种复合水凝胶包括一种亲疏性三嵌段共聚物（ABA）和一个由非共价相互作用结合的载荷胶束。所述载荷胶束包括一种生物活性物质和一种亲疏性二嵌段共聚物（CD）。所述A块包括一种类固醇重复单元（重复单元1），其具有主干碳酸酯和侧链带有类固醇官能团。每个A块的聚合度约为0.5到4.0。B块包括第一种聚（烷氧基）主干。C块包括第二种聚（烷氧基）主干。D块包括一种类固醇重复单元（重复单元2），其具有主干碳酸酯基和侧链包括类固醇官能团。该复合水凝胶能够控制释放生物活性物质。
• ANTIMICROBIAL POLYMERS AND METHODS OF MANUFACTURE THEREOF
  申请人：International Business Machines Corporation

  公开号：EP2516503B1

  公开（公告）日：2016-07-20
• BIODEGRADABLE POLYMERS, COMPLEXES THEREOF FOR GENE THERAPEUTICS AND DRUG DELIVERY, AND METHODS RELATED THERETO
  申请人：International Business Machines Corporation

  公开号：EP2516504B1

  公开（公告）日：2015-12-02