6-Methyl-3-prop-2-enyl-5-(2,3,5,6-tetrafluorophenyl)-1-(2,2,2-trifluoroethyl)piperidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 6-Methyl-3-prop-2-enyl-5-(2,3,5,6-tetrafluorophenyl)-1-(2,2,2-trifluoroethyl)piperidin-2-one
• 英文别名: 6-methyl-3-prop-2-enyl-5-(2,3,5,6-tetrafluorophenyl)-1-(2,2,2-trifluoroethyl)piperidin-2-one
• 化学式: C₁₇H₁₆F₇NO
• 分子量: 383.3
• InChiKey: SQYCRQQKULNQHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• ALIPHATIC SPIROLACTAM CGRP RECEPTOR ANTAGONISTS
  申请人：Merck Sharp & Dohme Corp.

  公开号：US20150203496A1

  公开（公告）日：2015-07-23

  The present invention is directed to aliphatic spirolactam derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical\compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

  本发明涉及脂肪族螺内酰胺衍生物，其为CGRP受体拮抗剂，可用于治疗或预防CGRP参与的疾病，如偏头痛。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗CGRP参与的这种疾病中的使用。
• US9227972B2
  申请人：——

  公开号：US9227972B2

  公开（公告）日：2016-01-05
• [EN] ALIPHATIC SPIROLACTAM CGRP RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR DE CGRP À BASE DE SPIROLACTAME ALIPHATIQUE
  申请人：MERCK SHARP & DOHME

  公开号：WO2013169574A2

  公开（公告）日：2013-11-14

  The present invention is directed to aliphatic spirolactam derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical\compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.