Methyl 4-[(4-amino-1-methylpiperidin-1-ium-1-yl)methyl]benzoate;2,2,2-trifluoroacetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Methyl 4-[(4-amino-1-methylpiperidin-1-ium-1-yl)methyl]benzoate;2,2,2-trifluoroacetate
• 英文别名: methyl 4-[(4-amino-1-methylpiperidin-1-ium-1-yl)methyl]benzoate;2,2,2-trifluoroacetate
• 化学式: C17H23F3N2O4
• 分子量: 376.4
• InChiKey: RPBUSCGSCHMCFL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.84
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  92.4
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：HAMPRECHT Dieter

  公开号：US20140088097A1

  公开（公告）日：2014-03-27

  The present invention relates to compounds of general formula (I) and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.

  本发明涉及通式(I)的化合物及其互变异构体和盐，特别是药学上可接受的盐，它们具有有价值的药理学特性，特别是对上皮钠通道的抑制作用，以及它们用于治疗疾病，特别是肺部和呼吸道疾病的用途。
• US8841309B2
  申请人：——

  公开号：US8841309B2

  公开（公告）日：2014-09-23
• [EN] HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES, MÉDICAMENTS CONTENANT CES COMPOSÉS, LEUR UTILISATION ET PROCÉDÉS DE LEUR PRÉPARATION
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2014044849A1

  公开（公告）日：2014-03-27

  The present invention relates to compounds of general formula (I), and the tautomers and the salts thereof, particularly the pharmaceutically acceptable salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on epithelial sodium channels, the use thereof for the treatment of diseases, particularly diseases of the lungs and airways.