3-(Difluoromethyl)-4,5-bis(4-hydroxybutyl)piperidine-1-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-(Difluoromethyl)-4,5-bis(4-hydroxybutyl)piperidine-1-carboxamide
• 英文别名: 3-(difluoromethyl)-4,5-bis(4-hydroxybutyl)piperidine-1-carboxamide
• 化学式: C₁₅H₂₈F₂N₂O₃
• 分子量: 322.39
• InChiKey: YVHZVHIYJNSFOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  86.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Novel Compositions for Preventing and/or Treating Lysosomal Storage Disorders
  申请人：Amicus Therapeutics, Inc.

  公开号：US20140086896A1

  公开（公告）日：2014-03-27

  The present invention provides novel compositions as well as methods for preventing and/or treating lysosomal storage disorders. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.

  本发明提供了新型组成物以及预防和/或治疗溶酶体贮存疾病的方法。特别是，本发明提供了预防和/或治疗高氏病的方法。
• Method for Treating Cerebral Amyloid Angiopathy Using Pharmacological Chaperones to Increase the Activity of Gangliosidases
  申请人：Amicus Therapeutics, Inc.

  公开号：US20150374733A1

  公开（公告）日：2015-12-31

  The present invention relates to a method for treating an individual having Cerebral Amyloid Angiopathy by using pharmacological chaperones to increase the activity of gangliosidase and/or sialidase enzymes involved in ganglioside catabolism.

  本发明涉及一种治疗患有脑淀粉样血管病的个体的方法，通过使用药理伴侣增加参与神经节苷脂降解的神经节苷脂酶和/或唾液酸酶酶活性。
• METHOD FOR TREATING ALZHEIMER'S DISEASE USING PHARMACOLOGICAL CHAPERONES TO INCREASE THE ACTIVITY OF GANGLIOSIDASES
  申请人：Amicus Therapeutics, Inc.

  公开号：EP2957295A1

  公开（公告）日：2015-12-23

  The present invention relates to a method for treating an individual having Alzheimer's Disease by using pharmacological chaperones to increase the activity of gangliosidase and/or sialidase enzymes involved in ganglioside catabolism.

  本发明涉及一种治疗阿尔茨海默氏症患者的方法，通过使用药理合剂来提高参与神经节苷脂分解代谢的神经节苷脂酶和/或硅糖苷酶的活性。
• Compositions for preventing and/or treating lysosomal storage disorders
  申请人：Amicus Therapeutics, Inc.

  公开号：US10035766B2

  公开（公告）日：2018-07-31

  The present invention provides novel compositions as well as methods for preventing and/or treating lysosomal storage disorders. In particular, the present invention provides methods for preventing and/or treating Gaucher's disease.

  本发明提供了预防和/或治疗溶酶体贮积症的新型组合物和方法。特别是，本发明提供了预防和/或治疗戈谢病的方法。
• Compositions for preventing and/or treating degenerative disorders of the central nervous system
  申请人：Amicus Therapeutics, Inc.

  公开号：US10421724B2

  公开（公告）日：2019-09-24

  The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the central nervous system. In particular, the present invention provides methods for preventing and/or treating Parkinson's disease.

  本发明提供了用于预防和/或治疗中枢神经系统退行性疾病的新型化合物以及使用这些化合物的组合物和方法。特别是，本发明提供了预防和/或治疗帕金森病的方法。