3-(1,2,3,4-Tetrahydropyridin-3-yl)thiophene-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 3-(1,2,3,4-Tetrahydropyridin-3-yl)thiophene-2-carboxylic acid
• 英文别名: 3-(1,2,3,4-tetrahydropyridin-3-yl)thiophene-2-carboxylic acid
• 化学式: C₁₀H₁₁NO₂S
• 分子量: 209.27
• InChiKey: ACMAXRBBGLUCMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  77.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] INHIBITORS OF HEPATITIS C VIRUS POLYMERASE<br/>[FR] INHIBITEURS DE LA POLYMÉRASE DU VIRUS DE L'HÉPATITE C
  申请人：COCRYSTAL DISCOVERY INC

  公开号：WO2014055142A1

  公开（公告）日：2014-04-10

  The present invention provides, among other things, compounds represented by the general Formula I:and pharmaceutically acceptable salts thereof, wherein X, Y, R2, and R3 are as defined in classes and subclasses herein and compositions (e.g., pharmaceutical compositions) comprising such compounds, which compounds are useful as inhibitors of hepatitis C virus polymerase, and thus are useful, for example, as medicaments for the treatment of HCV infection.