5-[(5-Fluoro-2-hydroxyphenyl)carbamoyl]-2-methylpiperidine-1-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 5-[(5-Fluoro-2-hydroxyphenyl)carbamoyl]-2-methylpiperidine-1-carboxylic acid
• 英文别名: 5-[(5-fluoro-2-hydroxyphenyl)carbamoyl]-2-methylpiperidine-1-carboxylic acid
• 化学式: C₁₄H₁₇FN₂O₄
• 分子量: 296.29
• InChiKey: BSQKMWLJZMVSRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  89.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• METHYLPIPERIDINE DERIVATIVE
  申请人：Abe Masahito

  公开号：US20140228377A1

  公开（公告）日：2014-08-14

  A compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which acts relying on an orexin (OX) receptor antagonistic activity and is useful for the treatment or prevention of diseases such as sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, head ache, migraine, pain, gastrointestinal diseases, epilepsy, inflammations, immune-related diseases, endocrine-related diseases and hypertension.

  一种由式（IA）表示的化合物或其药学上可接受的盐，其作用依赖于促进睡眠的荷尔蒙（OX）受体拮抗活性，可用于治疗或预防睡眠障碍、抑郁症、焦虑症、恐慌症、精神分裂症、药物依赖、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、进食障碍、头痛、偏头痛、疼痛、胃肠疾病、癫痫、炎症、免疫相关疾病、内分泌相关疾病和高血压等疾病的治疗。