1-(5-Tert-butyl-2-methyl-4,5-dihydro-1,3-oxazol-4-yl)ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 1-(5-Tert-butyl-2-methyl-4,5-dihydro-1,3-oxazol-4-yl)ethanone
• 英文别名: 1-(5-tert-butyl-2-methyl-4,5-dihydro-1,3-oxazol-4-yl)ethanone
• 化学式: C₁₀H₁₇NO₂
• 分子量: 183.25
• InChiKey: WFABMOTWEJOOLV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Azoline Compound and Azole Compound Library and Method for Producing Same
  申请人：Suga Hiroaki

  公开号：US20140113830A1

  公开（公告）日：2014-04-24

  An object of the present invention is to provide a method of efficiently constructing a library abundant in diversity and also usable for screening of a compound that binds to a target substance having protease activity. The present invention provides a method of constructing an azoline compound library containing two or more azoline compounds having an azoline backbone introduced into at least one of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof of Xaa 0 of a peptide represented by the following formula (I): A-(Xaa 0 ) n -B  (I) [wherein, m numbers of Xaa 0 s respectively represent arbitrary amino acids, at least one of which is an amino acid selected from the group consisting of Cys, Ser, Thr, and 2,3-diamino acid, and analogs thereof, m represents an inter selected from 2 to 40, and A and B each independently represent a peptide composed of from 0 to 100 amino acids].