7-(5-aminopentoxy)-2-N-(1-benzylpiperidin-4-yl)-2-N-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 7-(5-aminopentoxy)-2-N-(1-benzylpiperidin-4-yl)-2-N-[3-(dimethylamino)propyl]-6-methoxyquinazoline-2,4-diamine
• 化学式: C₃₁H₄₇N₇O₂
• 分子量: 549.8
• InChiKey: WJPLGDRJJBWWGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  40
• 可旋转键数：
  15
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• [EN] CELLULAR COMPOSITIONS USED TO RESTORE STEM CELL OR PROGENITOR CELL FUNCTION AND METHODS RELATED THERETO<br/>[FR] COMPOSITIONS CELLULAIRES UTILISÉES POUR LA RESTAURATION DE LA FONCTION DE CELLULES SOUCHES OU DE CELLULES PROGÉNITRICES ET PROCÉDÉS ASSOCIÉS
  申请人：UNIV EMORY

  公开号：WO2014074517A1

  公开（公告）日：2014-05-15

  This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions disclosed herein under conditions such that epigenetically altered cells are formed. In certain embodiments, methods of treating or preventing vascular or diabetic diseases or conditions are contemplated. In certain embodiments, epigenetically reprograming adult bone marrow- derived stem or progenitor cells including mesenchymal stem cells (MSCs) or endothelial progenitor cells (EPCs) for autologous treatments are contemplated.