US9777017, Example 53

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: US9777017, Example 53
• 英文别名: (Z)-5-amino-1-[(3S)-3-[4-[(1R)-1-hydroxyethyl]-12-thia-3,5,8-triazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,10-pentaen-3-yl]piperidin-1-yl]-4-methanimidoylpent-4-en-1-one
• 化学式: C₂₁H₂₆N₆O₂S
• 分子量: 426.5
• InChiKey: QQKFYGKILOEOKJ-FKQHZBSISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS
  申请人：Incyte Corporation

  公开号：US20160015695A1

  公开（公告）日：2016-01-21

  The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

  本发明提供了三环融合噻吩衍生物及其组合物和使用方法，可调节Janus激酶（JAK）的活性，并可用于治疗与JAK活性有关的疾病，包括但不限于炎症性疾病、自身免疫性疾病、癌症和其他疾病。
• Tricyclic fused thiophene derivatives as JAK inhibitors
  申请人：Incyte Corporation

  公开号：US11161855B2

  公开（公告）日：2021-11-02

  The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.

  本发明提供了三环融合噻吩衍生物及其组合物和使用方法，这些衍生物可调节Janus激酶（JAK）的活性，并可用于治疗与JAK活性有关的疾病，例如包括炎症性疾病、自身免疫性疾病、癌症和其他疾病。
• US9777017B2
  申请人：——

  公开号：US9777017B2

  公开（公告）日：2017-10-03
• [EN] TRICYCLIC FUSED THIOPHENE DERIVATIVES AS JAK INHIBITORS<br/>[FR] DÉRIVÉS DE THIOPHÈNE CONDENSÉS TRICYCLIQUES À TITRE D'INHIBITEURS DE JAK
  申请人：INCYTE CORP

  公开号：WO2014071031A1

  公开（公告）日：2014-05-08

  The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus kinase (JAK) and are useful in the treatment of diseases related to the activity of JAK including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.