1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-4-(methylamino)pyrimidin-2-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-4-(methylamino)pyrimidin-2-one
• 化学式: C₁₀H₁₄FN₃O₄
• 分子量: 259.23
• InChiKey: NCNLANLOLBSHPL-FJGDRVTGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  94.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE DISEASES<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE MALADIES AUTOIMMUNES
  申请人：KANDULA MAHESH

  公开号：WO2014068506A2

  公开（公告）日：2014-05-08

  The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing autoimmune diseases may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of rheumatoid arthritis, Crohn's disease, multiple sclerosis, systemic lupus erythematosus, dermatitis, ulcerative colitis, inflammatory bowel disease and other immune system related diseases.