1-chloroethyl 2-[4-[(2R)-2-[(E)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-6-oxopiperidin-1-yl]butoxy]acetate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-chloroethyl 2-[4-[(2R)-2-[(E)-4-(3-chlorophenyl)-3-hydroxybut-1-enyl]-6-oxopiperidin-1-yl]butoxy]acetate
• 化学式: C₂₃H₃₁Cl₂NO₅
• 分子量: 472.4
• InChiKey: AXQCZXAGNIZVPN-AHGVICBSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• SKIN WOUND HEALING AND SCAR REDUCTION WITH PROSTAGLANDIN EP4 AGONIST COMBINATIONS
  申请人：Allergan, Inc.

  公开号：US20140142042A1

  公开（公告）日：2014-05-22

  A combination of a prostaglandin EP4 agonist and an effective amount of: a prostaglandin EP2 agonist, a skin growth factor, a small peptide, a small inhibitory RNA targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine A2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars.
• [EN] SKIN WOUND HEALING AND SCAR REDUCTION WITH PROSTAGLANDIN EP4 AGONIST COMBINATIONS<br/>[FR] CICATRISATION D'UNE BLESSURE DE LA PEAU ET RÉDUCTION DE LA CICATRICE PAR DES COMBINAISONS D'AGONISTE DE PROSTAGLANDINE EP4
  申请人：ALLERGAN INC

  公开号：WO2014078446A2

  公开（公告）日：2014-05-22

  A combination of a prostaglandin EP4 agonist and an effective amount of : a prostaglandin EP2 agonist, a skin growth factor, a small peptide, a small inhibitory RNA targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine A2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars.