2-[2-[4-[1-(2-Fluoro-5-methoxyphenyl)-3-(2-methylpropyl)piperidin-4-yl]oxyphenyl]-4,5-dimethyl-3,4-dihydropyrazol-3-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2-[2-[4-[1-(2-Fluoro-5-methoxyphenyl)-3-(2-methylpropyl)piperidin-4-yl]oxyphenyl]-4,5-dimethyl-3,4-dihydropyrazol-3-yl]acetic acid
• 英文别名: 2-[2-[4-[1-(2-fluoro-5-methoxyphenyl)-3-(2-methylpropyl)piperidin-4-yl]oxyphenyl]-4,5-dimethyl-3,4-dihydropyrazol-3-yl]acetic acid
• 化学式: C₂₉H₃₈FN₃O₄
• 分子量: 511.6
• InChiKey: CPHZZAOENCEDMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  74.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• DIHYDROPYRAZOLE GPR40 MODULATORS
  申请人：Bristol-Meyers Squibb Company

  公开号：US20140142139A1

  公开（公告）日：2014-05-22

  The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

  本发明提供了I式化合物：或其立体异构体或其药学上可接受的盐，其中所有变量均如本文所定义。这些化合物是GPR40 G蛋白偶联受体调节剂，可用作药物。
• MATERIAL FOR ORGANIC ELECTROLUMINESCENCE DEVICE, AND ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：Takada Saki

  公开号：US20120181528A1

  公开（公告）日：2012-07-19

  A material for an organic electroluminescence device containing at least phosphorescent metal complex A and phosphorescent metal complex B, metal complex A and metal complex B are both organic metal complexes containing a metal having an atomic weight of 40 or more and a ligand, metal complex A has a specific structure, and metal complex B has the same structure with metal complex A except that one or more atoms directly bonding to ligand structures are substituted with atoms belonging to the same group of the atoms and having a greater atomic weight, and ratio of the content of metal complex B to the content of metal complex A is 0.005% by mass or more and 2% by mass or less.
• US9133163B2
  申请人：——

  公开号：US9133163B2

  公开（公告）日：2015-09-15