(2S,3R,4S,5R)-2,3,5,6-tetrahydroxy-4-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanal

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶二唑类
• 英文名称: (2S,3R,4S,5R)-2,3,5,6-tetrahydroxy-4-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanal
• 化学式: C12H14N4O8
• 分子量: 342.26
• InChiKey: HVCSCGBPUSIZMI-VVJJBPBLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  195
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• METHOD FOR DETECTING CANCER CELL USING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE, AND CANCER CELL-IMAGING AGENT COMPRISING FLUORESCENTLY LABELED L-GLUCOSE DERIVATIVE
  申请人：Yamada Katsuya

  公开号：US20140154717A1

  公开（公告）日：2014-06-05

  The purpose of the present invention is to provide a method for highly accurately detecting a cancer cell. The method of the present invention is characterized by comprising imaging with the use of a fluorescently labeled L-glucose derivative. By using the method and imaging agent according to the present invention, a high contrast between a cancer cell and a normal cell can be obtained compared with the case that imaging is conducted with the use of a fluorescently labeled D-glucose derivative. According to this method, moreover, no fasting is needed for the determination. Thus, the imaging can be quickly carried out without imposing a burden on a patient.

  本发明的目的是提供一种高精度检测癌细胞的方法。本发明的方法的特点在于使用荧光标记的L-葡萄糖衍生物进行成像。通过使用本发明的方法和成像剂，与使用荧光标记的D-葡萄糖衍生物进行成像相比，可以获得癌细胞和正常细胞之间的高对比度。此外，根据本方法，不需要进行禁食以进行确定，因此可以在不对患者造成负担的情况下快速进行成像。
• CANCER CELL DETECTION METHOD USING CELLS OF BIOLOGICAL ORIGIN
  申请人：Hirosaki University

  公开号：EP3199638A1

  公开（公告）日：2017-08-02

  The purpose of the present invention is to provide a novel cancer cell detection method that uses living body-derived cells and that can be used even in cytodiagnosis. In particular, the purpose of the present invention is to provide a novel cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with a pre-existing dyeing method for cytodiagnosis. Provided is a cancer cell detection method that uses living body-derived cells and that includes: incubating living cells included in a sample taken from a person together with a fluorescently-labeled L-glucose derivative and detecting the fluorescently-labeled L-glucose derivative that is taken up into the cells; and detecting fluorescence emitted by the L-glucose derivative that is present within the cells while the cells are attached to a thin glass or plastic plate. Also provided is a dual detection method for cancer cells in which the cancer cell detection method that uses living body-derived cells is combined with a dyeing method using cells that are fixed using an alcohol or the like.

  本发明的目的是提供一种新型的癌细胞检测方法，该方法使用源自人体的活细胞，甚至可用于细胞诊断。特别是，本发明的目的是提供一种新型癌细胞检测方法，该方法可对活体细胞进行成像，以及一种癌细胞双重检测方法，其中上述方法与用于细胞诊断的已有染色方法相结合。本发明提供了一种使用活体细胞的癌细胞检测方法，该方法包括：将取自人体的样本中的活细胞与荧光标记的 L-葡萄糖衍生物一起培养，并检测被吸收到细胞中的荧光标记的 L-葡萄糖衍生物；以及检测细胞附着在薄玻璃板或塑料板上时细胞内的 L-葡萄糖衍生物发出的荧光。此外，还提供了一种癌细胞双重检测方法，其中使用活体衍生细胞的癌细胞检测方法与使用酒精等固定细胞的染色方法相结合。
• Cancer cell detection method using living body-derived cells
  申请人：Hirosaki University

  公开号：US10551387B2

  公开（公告）日：2020-02-04

  A cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with a pre-existing dyeing method for cytodiagnosis. The method uses living body-derived cells and includes: incubating living cells included in a sample taken from a person together with a fluorescently-labeled L-glucose derivative and detecting the fluorescently-labeled L-glucose derivative that is taken up into the cells; and detecting fluorescence emitted by the L-glucose derivative that is present within the cells while the cells are attached to a thin glass or plastic plate. Also provided is a dual detection method for cancer cells in which the cancer cell detection method that uses living body-derived cells is combined with a dyeing method using cells that are fixed using an alcohol or the like.

  一种可对活体细胞进行成像的癌细胞检测方法，以及一种将上述方法与用于细胞诊断的已有染色方法相结合的癌细胞双重检测方法。该方法使用活体细胞，包括：将从人体内提取的样本中的活细胞与荧光标记的 L-葡萄糖衍生物一起孵育，并检测被吸收到细胞中的荧光标记的 L-葡萄糖衍生物；检测细胞附着在薄玻璃板或塑料板上时细胞内存在的 L-葡萄糖衍生物发出的荧光。此外，还提供了一种癌细胞双重检测方法，其中使用活体衍生细胞的癌细胞检测方法与使用酒精等固定细胞的染色方法相结合。
• CANCER CELL DETECTION METHOD USING LIVING BODY DERIVED CELLS
  申请人：Hirosaki University

  公开号：EP3199638B1

  公开（公告）日：2019-05-15
• CANCER CELL DETECTION METHOD USING LIVING BODY-DERIVED CELLS OF BIOLOGICAL ORIGIN
  申请人：Hirosaki University

  公开号：US20170315129A1

  公开（公告）日：2017-11-02

  The purpose of the present invention is to provide a novel cancer cell detection method that uses living body-derived cells and that can be used even in cytodiagnosis. In particular, the purpose of the present invention is to provide a novel cancer cell detection method that makes it possible to perform imaging of cells in a living state and a dual detection method for cancer cells in which the aforementioned method is combined with a pre-existing dyeing method for cytodiagnosis. Provided is a cancer cell detection method that uses living body-derived cells and that includes: incubating living cells included in a sample taken from a person together with a fluorescently-labeled L-glucose derivative and detecting the fluorescently-labeled L-glucose derivative that is taken up into the cells; and detecting fluorescence emitted by the L-glucose derivative that is present within the cells while the cells are attached to a thin glass or plastic plate. Also provided is a dual detection method for cancer cells in which the cancer cell detection method that uses living body-derived cells is combined with a dyeing method using cells that are fixed using an alcohol or the like.