N-(2,2-dimethylpropyl)-N-methyl-1-methylsulfonylpiperidin-4-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(2,2-dimethylpropyl)-N-methyl-1-methylsulfonylpiperidin-4-amine
• 化学式: C₁₂H₂₆N₂O₂S
• 分子量: 262.41
• InChiKey: BLBPBMXPHQWNBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Use of Pl3K Inhibitors for the Treatment of Obesity, Steatosis and Ageing
  申请人：Serrano Marugan Manuel

  公开号：US20140154232A1

  公开（公告）日：2014-06-05

  The first aspect of the invention relates to a phosphoinositide 3-kinase inhibitor for use in the treatment or prevention of a disease or condition associated with the expression of peroxisome proliferator-activated receptor gamma coactivator 1-α (Pgd1α) and/or uncoupling protein 1 (Thermogenin/Ucp1) in brown adipocytes. The disease or condition may be positive energy imbalance-associated, for example, obesity, an obesity-associated disease or condition, steatosis and biological aging (performance aging). Another aspect of the invention provides the use of a phosphoinositide 3-kinase inhibitor for promoting weight loss in an individual.