N-(2-phenylpiperidin-1-yl)oxyhydroxylamine;piperidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-(2-phenylpiperidin-1-yl)oxyhydroxylamine;piperidine
• 化学式: C16H27N3O2
• 分子量: 293.4
• InChiKey: BTDCOZIPBHKJAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  56.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• INSULIN DERIVATIVES FOR DIABETES TREATMENT
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20150320837A1

  公开（公告）日：2015-11-12

  Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.

  本文提供了一种“智能”递送治疗、预防或诊断药物的化合物、组合物和方法，例如通过葡萄糖感应胰岛素衍生物的葡萄糖介导递送胰岛素。胰岛素衍生物在体内结合血清白蛋白或聚集。在高血糖情况下，葡萄糖与葡萄糖感应元素的络合改变胰岛素衍生物的性质，导致其有效解离以释放胰岛素。这些化合物、组合物和方法提供了一种递送策略，用于自我调节和长期的糖尿病管理。
• COMPOSITIONS AND METHODS FOR FUNCTIONAL NUCLEIC ACID DELIVERY
  申请人：1MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20150322432A1

  公开（公告）日：2015-11-12

  Provided are derivatized therapeutic, prophylactic, or diagnostic agents, such as nucleic acids, that can be effectively delivered to cells and tissues. Also provided are methods of affecting a biological process by administering a therapeutic, prophylactic, or diagnostic agent, such as functional nucleic acid, to a cell or a subject, where the therapeutic, prophylactic, or diagnostic agent, such as functional nucleic acid, is derivatized therapeutic, prophylactic, or diagnostic agent, such as nucleic acid.
• US9867869B2
  申请人：——

  公开号：US9867869B2

  公开（公告）日：2018-01-16
• US9970002B2
  申请人：——

  公开号：US9970002B2

  公开（公告）日：2018-05-15
• [EN] COMPOSITIONS AND METHODS FOR FUNCTIONAL NUCLEIC ACID DELIVERY<br/>[FR] COMPOSITIONS ET MÉTHODES DE LIBÉRATION D'ACIDES NUCLÉIQUES FONCTIONNELS
  申请人：1MASSACHUSETTS INST OF TECHNOLOGY

  公开号：WO2014093688A1

  公开（公告）日：2014-06-19

  Provided are derivatized therapeutic, prophylactic, or diagnostic agents, such as nucleic acids, that can be effectively delivered to cells and tissues. Also provided are methods of affecting a biological process by administering a therapeutic, prophylactic, or diagnostic agent, such as functional nucleic acid, to a cell or a subject, where the therapeutic, prophylactic, or diagnostic agent, such as functional nucleic acid, is derivatized therapeutic, prophylactic, or diagnostic agent, such as nucleic acid.