2-[[1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-4-oxo-2-sulfanylidenepyrimidin-5-yl]methylamino]ethanesulfonic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: 2-[[1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-4-oxo-2-sulfanylidenepyrimidin-5-yl]methylamino]ethanesulfonic acid
• 英文别名: 2-[[1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-4-oxo-2-sulfanylidenepyrimidin-5-yl]methylamino]ethanesulfonic acid
• 化学式: C₁₆H₂₈N₃O₇PS₂
• 分子量: 469.5
• InChiKey: IRRSWLAEBPKCRI-RGCMKSIDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  189
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20150307542A1

  公开（公告）日：2015-10-29

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.

  本公开提供了修改的核苷酸，核苷酸和核酸，以及使用它们的方法。
• MODIFIED POLYNUCLEOTIDES ENCODING CD28 MOLECULE
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140171485A1

  公开（公告）日：2014-06-19

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160375134A1

  公开（公告）日：2016-12-29

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.