1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-3-methyl-2-methylidenepyrimidin-4-one

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: 1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-3-methyl-2-methylidenepyrimidin-4-one
• 英文别名: 1-[(2R,3R,4S,5R)-5-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]-3,4-dihydroxyoxolan-2-yl]-3-methyl-2-methylidenepyrimidin-4-one
• 化学式: C₁₅H₂₅N₂O₄P
• 分子量: 328.34
• InChiKey: GBMZWZOWOXVURT-NMFUWQPSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING COPPER METABOLISM (MURR1) DOMAIN CONTAINING 1
  申请人：Bancel Stephane

  公开号：US20140105965A1

  公开（公告）日：2014-04-17

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES ENCODING CD28 MOLECULE
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140171485A1

  公开（公告）日：2014-06-19

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• US9095552B2
  申请人：——

  公开号：US9095552B2

  公开（公告）日：2015-08-04