1-(2,2,3,3-Tetrafluoro-propane-1-sulfonyl)-butane

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 1-(2,2,3,3-Tetrafluoro-propane-1-sulfonyl)-butane
• 英文别名: 1-(2,2,3,3-Tetrafluoropropylsulfonyl)butane
• 化学式: C₇H₁₂F₄O₂S
• 分子量: 236.231
• InChiKey: FLUNTZSBFAICPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(2,2,3,3-Tetrafluoro-propane-1-sulfonyl)-butane 在 氨 作用下， 以 苯 为溶剂， 反应 2.0h， 以81%的产率得到2-amino-1-butylsulfonyl-3,3-difluoro-1-propene
  参考文献：
  名称：

  摘要：

  2,2,3,3-Tetrafluoropropyl and 2,2,3,3,4,4,5,5-octafluoropentyl alkyl sulfones react with ammonia, primary and secondary amines, hydrazine hydrate, phenylhydrazine, and N,N-dimethylhydrazine to afford, depending on the length of the polyfluoroalkyl chain and reaction conditions, the corresponding enamines, imines, or mono- and bis-hydrazones. The bis-hydrazone obtained from phenylhydrazine and 2,2,3,3,4,4,5,5-octafluoropentyl benzyl sulfone is capable of undergoing further dehydrofluorination to give 5-difluoronlethyl or 5-unsubstituted 1-phenylpyrazole.

  DOI：

  10.1023/a:1012427229154

文献信息

• ——
  作者：V. M. Timoshenko、Ya. V. Nikolin、N. P. Kolesnik、Yu. G. Shermolovich

  DOI：10.1023/a:1012427229154

  日期：——

  2,2,3,3-Tetrafluoropropyl and 2,2,3,3,4,4,5,5-octafluoropentyl alkyl sulfones react with ammonia, primary and secondary amines, hydrazine hydrate, phenylhydrazine, and N,N-dimethylhydrazine to afford, depending on the length of the polyfluoroalkyl chain and reaction conditions, the corresponding enamines, imines, or mono- and bis-hydrazones. The bis-hydrazone obtained from phenylhydrazine and 2,2,3,3,4,4,5,5-octafluoropentyl benzyl sulfone is capable of undergoing further dehydrofluorination to give 5-difluoronlethyl or 5-unsubstituted 1-phenylpyrazole.