3-[(3S,4R)-3-methyl-1-[(1R,3S)-2-oxo-3-propan-2-yl-3-[[6-(trifluoromethyl)-2,4-dihydro-1,3-benzoxazin-3-yl]methyl]cyclopentyl]piperidin-4-yl]benzoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-[(3S,4R)-3-methyl-1-[(1R,3S)-2-oxo-3-propan-2-yl-3-[[6-(trifluoromethyl)-2,4-dihydro-1,3-benzoxazin-3-yl]methyl]cyclopentyl]piperidin-4-yl]benzoic acid
• 化学式: C₃₁H₃₇F₃N₂O₄
• 分子量: 558.6
• InChiKey: NJWAWYJCCYVIOT-XOJJSJOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  40
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• Methods of Treating Inflammatory Diseases by Targeting the Chemoattractant Cytokine Receptor 2 (CCR2) or Chemokine (C-C motif) Ligand 2 (CCL2)
  申请人：Weiner Howard

  公开号：US20140178367A1

  公开（公告）日：2014-06-26

  Methods of treating inflammatory diseases, e.g., diseases associated with inflammatory CD14+/CD16− monocytes, e.g., amyotrophic lateral sclerosis (ALS), stroke, and glaucoma, using compounds such as small molecules and antibodies that target CCR2 or CCL2.
• GASTROINTESTINAL TRACT DETECTION METHODS, DEVICES AND SYSTEMS
  申请人：Progenity Inc.

  公开号：US20180206726A1

  公开（公告）日：2018-07-26

  The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.