3-[4-(Hydroxymethyl)piperidin-1-ium-1-yl]propanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-[4-(Hydroxymethyl)piperidin-1-ium-1-yl]propanoate
• 英文别名: 3-[4-(hydroxymethyl)piperidin-1-ium-1-yl]propanoate
• 化学式: C9H17NO3
• 分子量: 187.24
• InChiKey: YSRUAWYMMBRSMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  64.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] THERAPEUTIC COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS THÉRAPEUTIQUES ET LEURS UTILISATIONS
  申请人：GENENTECH INC

  公开号：WO2016123387A1

  公开（公告）日：2016-08-04

  Provided herein are compounds of formula I: and salts thereof and compositions and uses thereof. The compounds are useful as inhibitors of LSD1. Also included are pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various LSD1-mediated disorders.

  本文提供了公式I的化合物及其盐、组合物和用途。这些化合物可用作LSD1的抑制剂。还包括含有公式I化合物或其药用盐的药物组合物，以及在治疗各种LSD1介导的疾病中使用这些化合物和盐的方法。
• FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
  申请人：Biomatrica, Inc.

  公开号：EP2934572A2

  公开（公告）日：2015-10-28
• THERAPEUTIC COMPOUNDS AND USES THEREOF
  申请人：Genentech, Inc.

  公开号：EP3250552A1

  公开（公告）日：2017-12-06
• [EN] FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS<br/>[FR] FORMULATIONS ET PROCÉDÉS POUR STABILISER DES RÉACTIFS PCR
  申请人：BIOMATRICA INC

  公开号：WO2014100755A2

  公开（公告）日：2014-06-26

  Described herein are stabilized polymerase compositions comprising a polymerase and an polymerase stabilizing agent, such as a non-detergent zwitterionic stabilizer or a cationic ester disclosed, for use in nucleic acid amplification or nucleic acid sequencing. Compositions are provided for the stabilization of one or more polymerases in a single stabilized liquid formulation. Also disclosed are methods for making and using stabilized polymerase compositions and kits for nucleic acid amplification and sequencing comprising the stabilized polymerase compositions provided.