3-[[3-(hydroxymethyl)-4-methoxyphenyl]methyl]-6-[3-(4-methylpiperidin-1-yl)-3-oxopropyl]-4H-1,2,4-triazin-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 3-[[3-(hydroxymethyl)-4-methoxyphenyl]methyl]-6-[3-(4-methylpiperidin-1-yl)-3-oxopropyl]-4H-1,2,4-triazin-5-one
• 化学式: C₂₁H₂₈N₄O₄
• 分子量: 400.5
• InChiKey: ICFDUJWUCOOHLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  29
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Collagen Stimulators and Their Use in the Treatment of Skin
  申请人：AVON PRODUCTS, INC.

  公开号：US20140179641A1

  公开（公告）日：2014-06-26

  Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ cosmetic composition comprising novel active agents that enhance collagen production in the skin.
• PLOD-2 Modulators and Their Use in the Treatment of Skin
  申请人：AVON PRODUCTS, INC.

  公开号：US20140179688A1

  公开（公告）日：2014-06-26

  Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents that modulate the PLOD-2 enzyme in the skin. Also provided are methods for screening for substances which modulate PLOD-2 enzyme levels and the methods of using active agents identified by the screening protocol in the treatment of skin.
• US8901122B2
  申请人：——

  公开号：US8901122B2

  公开（公告）日：2014-12-02
• US9283163B2
  申请人：——

  公开号：US9283163B2

  公开（公告）日：2016-03-15