5-chloro-N-formyl-N-[[(5R)-2-methylidene-3-[4-[2-(2-oxopropoxy)ethylamino]phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-chloro-N-formyl-N-[[(5R)-2-methylidene-3-[4-[2-(2-oxopropoxy)ethylamino]phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide
• 化学式: C₂₂H₂₄ClN₃O₅S
• 分子量: 478.0
• InChiKey: IWFIVZAFIAKFLW-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  116
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] ALDEHYDE DERIVATIVE OF SUBSTITUTE OXAZOLIDINONES<br/>[FR] DÉRIVÉ ALDÉHYDE D'OXALIDINONES SUBSTITUÉES
  申请人：WANBURY LTD

  公开号：WO2014102822A2

  公开（公告）日：2014-07-03

  The present invention concern towards the prodrug of 5-chloro-N-((5S)-2-oxo-3-[4-(3- oxo-morpholin-4-yl)phenyl]-l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, rivaroxaban per se; processes for their preparation, and the application in treatment and/or prophylaxis of diseases, especially of thromboembolic disorders. The prodrug of compound formula (B) is chemically designated as5-chloro-N-formyl-N-((5S)-2-oxo-3-[4-(3- oxomorpholin-4-yl)phenyl]- l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide.(I)