(3S,4R,5R)-2-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-5-(2-methylidene-4-methyliminopyrimidin-1-yl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: (3S,4R,5R)-2-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-5-(2-methylidene-4-methyliminopyrimidin-1-yl)oxolane-3,4-diol
• 英文别名: (3S,4R,5R)-2-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]-5-(2-methylidene-4-methyliminopyrimidin-1-yl)oxolane-3,4-diol
• 化学式: C₁₅H₂₆N₃O₃P
• 分子量: 327.36
• InChiKey: CZVSDBQWCFYSAG-YKYOPCIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  77.3
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20140193482A1

  公开（公告）日：2014-07-10

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20160151516A1

  公开（公告）日：2016-06-02

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• US9827332B2
  申请人：——

  公开号：US9827332B2

  公开（公告）日：2017-11-28