(3S,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3S,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol
• 化学式: C₆H₁₃NO₄
• 分子量: 163.17
• InChiKey: LXBIFEVIBLOUGU-RBIOSCOISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  93
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• METHOD TO PREDICT RESPONSE TO PHARMACOLOGICAL CHAPERONE TREATMENT OF DISEASES
  申请人：AMICUS THERAPEUTICS, INC.

  公开号：US20140206721A1

  公开（公告）日：2014-07-24

  The present invention provides methods to determine whether a patient with a lysosomal storage disorder win benefit from treatment with a specific pharmacological chaperone. The present invention exemplifies an in vitro method for determining α-galactosidase A responsiveness to a pharmacological chaperone such as 1-deoxygalactonojirimycin in a cell line expressing a mutant from of α-galactosidase A. The invention also provides a method for diagnosing Fabry disease in patients suspected of having Fabry disease.
• Methods for Treatment of Fabry Disease
  申请人：Amicus Therapeutics, Inc.

  公开号：US20150238474A1

  公开（公告）日：2015-08-27

  Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.
• US9000011B2
  申请人：——

  公开号：US9000011B2

  公开（公告）日：2015-04-07
• US9095584B2
  申请人：——

  公开号：US9095584B2

  公开（公告）日：2015-08-04
• US9206457B2
  申请人：——

  公开号：US9206457B2

  公开（公告）日：2015-12-08