N-[1-[(4-cyanophenyl)methyl]piperidin-4-yl]-5-[4-(4-propylsulfonylphenyl)piperazine-1-carbonyl]pyridine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: N-[1-[(4-cyanophenyl)methyl]piperidin-4-yl]-5-[4-(4-propylsulfonylphenyl)piperazine-1-carbonyl]pyridine-2-carboxamide
• 化学式: C₃₃H₃₈N₆O₄S
• 分子量: 614.8
• InChiKey: QEZUBDQHEOEYJL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  135
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• AMPK-activating heterocyclic compounds and methods for using the same
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US10377742B2

  公开（公告）日：2019-08-13

  Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R3, R4, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

  所公开的是取代的吡啶化合物以及药物组合物和使用方法。其中一种化合物具有如下结构 其中 E、J、T、以 "B "表示的环系、T、R3、R4、w 和 x 如本文所述。在某些实施方案中，本文公开的化合物可激活 AMPK 通路，并可用于治疗与代谢相关的疾病和病症。
• AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME
  申请人：Goff Dane

  公开号：US20180057478A1

  公开（公告）日：2018-03-01

  Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted by “B”, T, R 3 , R 4 , w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.
• US8791136B2
  申请人：——

  公开号：US8791136B2

  公开（公告）日：2014-07-29
• US9663496B2
  申请人：——

  公开号：US9663496B2

  公开（公告）日：2017-05-30