(2R,3R,4S,5R)-2-(4-amino-5-ethyl-2-methylidenepyrimidin-1-yl)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: (2R,3R,4S,5R)-2-(4-amino-5-ethyl-2-methylidenepyrimidin-1-yl)-5-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]oxolane-3,4-diol
• 英文别名: (2R,3R,4S,5R)-2-(4-amino-5-ethyl-2-methylidenepyrimidin-1-yl)-5-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]oxolane-3,4-diol
• 化学式: C₁₆H₂₈N₃O₃P
• 分子量: 341.39
• InChiKey: DMPTUAVRTQZYED-IXYNUQLISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  91.3
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING AQUAPORIN-5
  申请人：Bancel Stephane

  公开号：US20140105964A1

  公开（公告）日：2014-04-17

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• MODIFIED POLYNUCLEOTIDES FOR TREATING GALACTOSYLCERAMIDASE PROTEIN DEFICIENCY
  申请人：Moderna Therapeutics, Inc.

  公开号：US20140221465A1

  公开（公告）日：2014-08-07

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• METHODS OF INCREASING THE VIABILITY OR LONGEVITY OF AN ORGAN OR ORGAN EXPLANT
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20150051268A1

  公开（公告）日：2015-02-19

  The invention relates to compositions and methods for the manufacture and optimization of modified mRNA molecules for their use in improving organ viability and/or longevity.
• MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160158385A1

  公开（公告）日：2016-06-09

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• US9089604B2
  申请人：——

  公开号：US9089604B2

  公开（公告）日：2015-07-28