2-[(3R)-3-(2-fluoroprop-2-enyl)-3,6,6-trimethyl-1,1-dioxo-2H-1,4-thiazin-2-yl]ethanol

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 2-[(3R)-3-(2-fluoroprop-2-enyl)-3,6,6-trimethyl-1,1-dioxo-2H-1,4-thiazin-2-yl]ethanol
• 化学式: C₁₂H₂₀FNO₃S
• 分子量: 277.36
• InChiKey: OWTKGAHXRDVDTM-TVKKRMFBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  75.1
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] FUSED MULTICYCLIC 3-AMINO-5,6-DIHYDRO-2H-1,4-THIAZINE DERIVATIVES AND THEIR USE AS BETA-SECRETASE INHIBITORS<br/>[FR] DÉRIVÉS DE 3-AMINO-5,6-DIHYDRO-2H-1,4-THIAZINE MULTICYCLIQUES CONDENSÉS ET LEUR UTILISATION À TITRE D'INHIBITEURS DE BÊTA-SÉCRÉTASE
  申请人：AMGEN INC

  公开号：WO2014120658A1

  公开（公告）日：2014-08-07

  The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A5, A6, A8, R1, R2, R3, R7, X, Y, n and o of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formula II and sub-formula embodiments thereof, compounds of Formula III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III, and sub-Formulas thereof.