4-[(4-Benzylcyclopenta-1,3-dien-1-yl)methyl]-1-azatricyclo[3.3.1.13,7]decane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 4-[(4-Benzylcyclopenta-1,3-dien-1-yl)methyl]-1-azatricyclo[3.3.1.13,7]decane
• 英文别名: 4-[(4-benzylcyclopenta-1,3-dien-1-yl)methyl]-1-azatricyclo[3.3.1.13,7]decane
• 化学式: C₂₂H₂₇N
• 分子量: 305.5
• InChiKey: UVWCPQBPORZVNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• NEURONAL NICOTINIC AGONISTS AND METHODS OF USE
  申请人：AbbVie Inc.

  公开号：US20150313891A1

  公开（公告）日：2015-11-05

  An embodiment relates to a selective agonist of neuronal nicotinic acetylcholine receptor α7 subtype, a pharmaceutically suitable salt, prodrug, or a metabolite thereof, for the prevention and treatment of diseases and conditions that are mediated by nicotinic acetylcholine receptors, and methods of use thereof. Another embodiment is a method of administering a pharmaceutically effective amount of a selective agonist of neuronal nicotinic acetylcholine receptor α7 subtype, or a pharmaceutically suitable salt, prodrug, or a metabolite thereof, to a mammal in need thereof.
• US8802693B1
  申请人：——

  公开号：US8802693B1

  公开（公告）日：2014-08-12