4-Propan-2-yl-1,2-dihydroimidazol-5-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑啉类
• 英文名称: 4-Propan-2-yl-1,2-dihydroimidazol-5-one
• 英文别名: 4-propan-2-yl-1,2-dihydroimidazol-5-one
• 化学式: C₆H₁₀N₂O
• 分子量: 126.16
• InChiKey: OFSHRMAWVSLOIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• CYCLOSPORIN DERIVATIVES
  申请人：Fischer Gunter

  公开号：US20140316104A1

  公开（公告）日：2014-10-23

  The present invention relates to novel cyclosporin derivatives that do not cross the cellular membrane. The compounds according to the invention are used in medicine, more particularly in the treatment/diagnosis of acute and chronic inflammatory diseases, viral infections, cancer, degenerative muscle diseases, neurodegenerative diseases and damage that is associated with calcium homeostasis impairment. The novel cyclosporin derivatives additionally have no immunosuppressive effect.

  本发明涉及一种新型环孢霉素衍生物，其不穿过细胞膜。本发明的化合物用于医学，特别是用于治疗/诊断急性和慢性炎症性疾病、病毒感染、癌症、退行性肌肉疾病、神经退行性疾病以及与钙稳态障碍相关的损伤。这些新型环孢霉素衍生物还没有免疫抑制作用。
• SORBENT COMPRISING AN AROMATIC RING SYSTEM ON ITS SURFACE FOR THE PURIFICATION OF ORGANIC MOLECULES
  申请人：INSTRACTION GMBH

  公开号：US20140243512A1

  公开（公告）日：2014-08-28

  In a first embodiment the present invention relates to a sorbent comprising a porous inorganic solid support material having on its surface a film of a crosslinked polyvinylamine comprising derivatized amine groups and amine groups binding to the surface of the support material via electron donor/acceptor interactions. In a second embodiment the present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbents according to the invention for the purification of organic molecules, in particular pharmaceutical active compounds, preferably in chromatographic applications.
• US20140343261A1
  申请人：——

  公开号：US20140343261A1

  公开（公告）日：2014-11-20
• SORBENT COMPRISING ON ITS SURFACE AN AROMATIC RING SYSTEM HAVING AN ANIONIC OR DEPROTONIZABLE GROUP FOR THE PURIFICATION OF ORGANIC MOLECULES
  申请人：INSTRACTION GMBH

  公开号：US20150045545A1

  公开（公告）日：2015-02-12

  The present invention relates to a sorbent comprising a solid support material, the surface of which comprises a residue of a general formula (I), wherein the residue is attached via a covalent single bond to a functional group on the surface of either the bulk solid support material itself or of a polymer film on the surface of the solid support material. Furthermore, the present invention relates to the use of the sorbent according to the invention for the purification of organic molecules, in particular pharmaceutically active compounds, preferably in chromatographic applications.
• INHIBITORS OF ALPHA-AMINO-BETA-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
  申请人：TES Pharma S.r.l.

  公开号：US20160060226A1

  公开（公告）日：2016-03-03

  The present disclosure discloses compounds capable of modulating the activity of α-amino-β-carboxymuconic acid semialdehyde decarboxylase (ACMSD), which are useful for the prevention and/or the treatment of diseases and disorders associated with defects in NAD + biosynthesis, e.g., metabolic disorders, neurodegenerative diseases, chronic inflammatory diseases, kidney diseases, and diseases associated with ageing. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament.