[(E)-2-[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-[hydroxy(methyl)phosphinothioyl]oxy-4-methoxyoxolan-2-yl]ethenyl]phosphonic acid

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: [(E)-2-[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-[hydroxy(methyl)phosphinothioyl]oxy-4-methoxyoxolan-2-yl]ethenyl]phosphonic acid
• 化学式: C₁₂H₁₈N₂O₉P₂S
• 分子量: 428.29
• InChiKey: VBXOOLJEMCEDSW-WKHANDADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  187
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE
  申请人：Chang Wonsuk

  公开号：US20160068837A1

  公开（公告）日：2016-03-10

  The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5′ modified nucleotides that comprise, among other potential modifications, a 2′ internucleoside linkage. The invention further relates to 5′ modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.

  本发明涉及RNAi分子及其组成物，包括连接在反义链5'端的位置1核苷酸和位置2核苷酸之间的2'间核苷酸连接。具体而言，本发明涉及能够介导RNA干扰的单链和双链短干扰核酸（siNA）分子，其包含5'修饰核苷酸，其中包括2'间核苷酸连接等其他潜在修饰。本发明还涉及用作试剂的5'修饰核苷酸，用于生成本发明的RNAi分子以及使用所述RNAi分子的方法。
• Short interfering nucleic acid (siNA) molecules containing a 2′ internucleoside linkage (3dT)
  申请人：SIRNA THERAPEUTICS, INC.

  公开号：US10738308B2

  公开（公告）日：2020-08-11

  The present invention relates to RNAi molecules, and compositions thereof, comprising a 2′ internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5′ end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5′ modified nucleotides that comprise, among other potential modifications, a 2′ internucleoside linkage. The invention further relates to 5′ modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.

  本发明涉及RNAi分子及其组合物，其包含连接反义链5′端的1位核苷酸和2位核苷酸的2′核苷间连接。具体地说，本发明涉及能够介导 RNA 干扰的单链和双链短干扰核酸（siNA）分子，这些分子包含 5′修饰的核苷酸，这些核苷酸除其他可能的修饰外，还包含 2′核苷间连接。本发明进一步涉及用作试剂生成本发明 RNAi 分子的 5′修饰核苷酸以及使用所公开 RNAi 分子的方法。
• [EN] SHORT INTERFERING NUCLEIC ACID (siNA) MOLECULES CONTAINING A 2' INTERNUCLEOSIDE LINKAGE<br/>[FR] MOLÉCULES D'ACIDE NUCLÉIQUE INTERFÉRENT COURT (ANSI) CONTENANT UN ENCHAÎNEMENT INTERNUCLÉOSIDE 2'
  申请人：SIRNA THERAPEUTICS INC

  公开号：WO2014130607A1

  公开（公告）日：2014-08-28

  The present invention relates to RNAi molecules, and compositions thereof, comprising a 2' internucleoside linkage connecting the nucleotide at position 1 and the nucleotide at position 2 at the 5' end of the antisense strand. Specifically, the invention relates to single- and double-stranded short interfering nucleic acid (siNA) molecules that are capable of mediating RNA interference comprising 5' modified nucleotides that comprise, among other potential modifications, a 2' internucleoside linkage. The invention further relates to 5' modified nucleotides used as reagents to generate the RNAi molecules of the invention and methods of using the disclosed RNAi molecules.