(3Z,5E)-3,5-bis[(3-bromophenyl)methylidene]-1-methylpiperidin-4-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: (3Z,5E)-3,5-bis[(3-bromophenyl)methylidene]-1-methylpiperidin-4-one
• 化学式: C₂₀H₁₇Br₂NO
• 分子量: 447.2
• InChiKey: KHBXHLSTIOLHQI-VAQFQWRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• METHOD FOR THE PROGNOSIS OF ACUTE PROMYELOCYTIC LEUKEMIA
  申请人：Epi-C S.r.L.

  公开号：EP3458607B1

  公开（公告）日：2021-10-06
• METHOD FOR THE PROGNOSIS AND/OR TREATMENT OF ACUTE PROMYELOCYTIC LEUKEMIA
  申请人：EPI-C S.R.L.

  公开号：US20190284635A1

  公开（公告）日：2019-09-19

  The present invention relates to a method for the diagnosis of low overall survival acute promyelocytic leukemia and/or of predicting and/or monitoring the response and/or the efficacy of a therapy for acute promyelocytic leukemia or to identify a subject to be treated with an inhibitor of HAT and/or an inhibitor of EZH2 by determining the acetylation or methylation status of specific relevant regions and relative kit and microarray. The invention also refers to histone acetyl transferase (HAT) inhibitor for use in the treatment of a solid or hematopoietic tumor.