(2R,3S,4R,5R)-2-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-5-(6-ethoxy-2-methylpurin-9-yl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: (2R,3S,4R,5R)-2-[2-[dimethyl(methylidene)-lambda5-phosphanyl]ethyl]-5-(6-ethoxy-2-methylpurin-9-yl)oxolane-3,4-diol
• 英文别名: (2R,3S,4R,5R)-2-[2-[dimethyl(methylidene)-λ5-phosphanyl]ethyl]-5-(6-ethoxy-2-methylpurin-9-yl)oxolane-3,4-diol
• 化学式: C₁₇H₂₇N₄O₄P
• 分子量: 382.4
• InChiKey: SJDCXEMZVOLIKI-LSCFUAHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• MODIFIED POLYNUCLEOTIDES ENCODING AQUAPORIN-5
  申请人：Bancel Stephane

  公开号：US20140105964A1

  公开（公告）日：2014-04-17

  The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
• US20140255468A1
  申请人：——

  公开号：US20140255468A1

  公开（公告）日：2014-09-11
• MODIFIED NUCLEIC ACID MOLECULES AND USES THEREOF
  申请人：Moderna Therapeutics, Inc.

  公开号：US20160354491A1

  公开（公告）日：2016-12-08

  The present disclosure provides modified nucleosides, nucleotides, and nucleic acids, and methods of using them.
• ENZYMES AND POLYMERASES FOR THE SYNTHESIS OF RNA
  申请人：ModernaTX, Inc.

  公开号：US20170130255A1

  公开（公告）日：2017-05-11

  The invention relates to compositions and methods for the design, evolution, preparation, and/or manufacture of enzymes for use with polynucleotides, primary transcripts and mmRNA molecules.
• US9220792B2
  申请人：——

  公开号：US9220792B2

  公开（公告）日：2015-12-29