isophthalic acid bis-pentafluorophenyl ester | 92996-14-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 缩酚酸和缩酚酸环醚类
• 英文名称: isophthalic acid bis-pentafluorophenyl ester
• 英文别名: 1,3-Benzenedicarboxylic acid, bis(pentafluorophenyl) ester；bis(2,3,4,5,6-pentafluorophenyl) benzene-1,3-dicarboxylate
• CAS: 92996-14-0
• 化学式: C₂₀H₄F₁₀O₄
• 分子量: 498.233
• InChiKey: VYILPLVQROQKGH-UHFFFAOYSA-N

物化性质

• 沸点：
  545.2±50.0 °C(Predicted)
• 密度：
  1.669±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  isophthalic acid bis-pentafluorophenyl ester 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 生成
  参考文献：
  名称：

  Macrocyclic oligomers of isophthalic acid and trans-1,2-diaminocyclohexane — building blocks for synthetic peptide receptors

  摘要：

  New macrocyclic oligomers of isophthalic acid and trans-1,2-diaminocyclohexane are readily prepared and useful in the synthesis of new, sequence-selective receptors for peptides. Such receptors have a simple, two-armed structural motif and the peptide sequences they bind vary with the ring size of the macrocyclic arms. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0040-4039(96)02040-0
• 作为产物：
  描述：

  间苯二甲酸 、 五氟苯酚 在 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 isophthalic acid bis-pentafluorophenyl ester
  参考文献：
  名称：

  Mezo; Seprodi; Erchegyi, Acta Chimica Hungarica, 1984, vol. 116, # 2, p. 173 - 187

  摘要：

  DOI：

文献信息

• Simple synthetic receptors that bind peptides in water
  作者：Mercedes Torneiro、W. Clark Still

  DOI：10.1016/s0040-4020(97)90388-4

  日期：1997.6

  A simple two-armed receptor has been prepared that binds certain peptides sequence-selectively in water at pH 4.

  制备了一种简单的双臂受体，其在pH 4的水中选择性地结合某些肽。
• Synthesis and binding properties of cyclodextrin trimers
  作者：David K Leung、Joshua H Atkins、Ronald Breslow

  DOI：10.1016/s0040-4039(01)01200-x

  日期：2001.9

  A series of cyclodextrin trimers and dimers were prepared and examined as binders for appropriate trimeric and dimeric aminoacid amides. Tritopic binding was stronger than ditopic binding, although the free energies were not strictly additive. Such trimers are attractive prospects for the binding of polypeptides and proteins.

  制备了一系列环糊精三聚体和二聚体，并作为适当的三聚和二聚氨基酸酰胺的粘合剂进行了检查。三位结合比二位结合更强，尽管自由能不是严格加和的。这样的三聚体是结合多肽和蛋白质的诱人前景。
• SYNTHETIC RECEPTORS, LIBRARIES AND USES THEREOF
  申请人：——

  公开号：US20030104360A1

  公开（公告）日：2003-06-05

  The invention is directed to synthetic receptor(s) which comprises a polyfunctional organic template covalently linked to two or more oligomers which may independently be the same or different and may independently be straight chain, cyclic or branched. The template may be linked to an identifier which uniquely defines the synthetic receptor. The identifier is a stable chemical molecule or a plurality of stable chemical molecules distinguishable and detectable to picomolar levels or may be an oligonucleotide. In a preferred embodiment, the template is covalently linked to a solid support which is linked to an identifier. In addition, the invention includes methods of preparing synthetic receptors and synthetic receptor libraries. The synthetic library may be linked with identifiers such that the library comprises a plurality of different synthetic receptor members. The invention also provides methods for assaying a synthetic receptor library to determine suitable synthetic receptor(s) which (a) bind an acceptor molecule; (b) exhibit biological activity; (c) which catalyze a reaction or inhibit a catalyzed reaction; and (d) separate compounds in chromatography.

  本发明涉及合成受体，其包括一个多功能有机模板，与两个或更多寡聚物共价连接，这些寡聚物可以独立地相同或不同，并且可以独立地为直链、环状或支链。该模板可以与一个标识符连接，该标识符唯一定义合成受体。标识符是一个稳定的化学分子或多个稳定的化学分子，可以区分和检测到皮克摩尔级别，或者可以是寡核苷酸。在一种首选实施例中，该模板与固体支持体共价连接，该固体支持体与标识符连接。此外，本发明还包括制备合成受体和合成受体库的方法。合成库可以与标识符连接，使库包括多个不同的合成受体成员。本发明还提供了一种测定合成受体库以确定适合的合成受体的方法，这些合成受体可以(a)结合受体分子；(b)表现生物活性；(c)催化反应或抑制催化反应；以及(d)在色谱分离化合物中。
• A Synthetic Receptor Motif Designed for Extended Peptide Conformations
  作者：Kevin Ryan、Leland J Gershell、W Clark Still

  DOI：10.1016/s0040-4020(00)00252-0

  日期：2000.5

  The intrinsic flexibility of short peptides makes them difficult targets for molecular recognition. Although in general too short to form stable secondary structures, many are able to sample extended conformations. Using monomer cycloalkyl-1,2-trans-diamines alternated with cycloalkyl-1,2-trans-dicarboxylic acids, we have constructed a novel receptor motif to be complementary to extended tripeptides. Receptor design, synthesis, structural analysis and binding studies are presented. (C) 2000 Elsevier Science Ltd. All rights reserved.
• EP0739486A4
  申请人：——

  公开号：EP0739486A4

  公开（公告）日：1998-09-09