(3S,4R)-2-(6-aminopurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 5'-脱氧核糖核苷
• 英文名称: (3S,4R)-2-(6-aminopurin-9-yl)-5-(chloromethyl)oxolane-3,4-diol
• 化学式: C₁₀H₁₂ClN₅O₃
• 分子量: 285.69
• InChiKey: IYSNPOMTKFZDHZ-JYQXIPBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] COMPOSITIONS COMPRISING SELENIUM AND USE OF SAME FOR THE TREATMENT AND PREVENTION OF DISEASE OR CONDITIONS ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION<br/>[FR] COMPOSITIONS COMPRENANT DU SÉLÉNIUM ET UTILISATION DE CELLES-CI POUR LE TRAITEMENT ET LA PRÉVENTION DE MALADIE OU D'ÉTATS ASSOCIÉS AVEC UN DYSFONCTIONNEMENT MITOCHONDRIAL
  申请人：ALLTECH INC

  公开号：WO2014144776A1

  公开（公告）日：2014-09-18

  The present application relates to compositions comprising selenium (e.g., selenium enriched yeast and selenium containing compounds obtained or derived therefrom) and methods of using the same to treat and inhibit obesity, diabetes and related conditions. In particular, the present application provides compositions comprising selenium enriched yeast (e.g., selenium enriched yeast comprising 2% or less inorganic selenium), selenium containing compounds present therein and/or derived therefrom, and methods of using the same to enhance mitochondrial activity and function (e.g., in skeletal muscle and liver) in a subject (e.g., as a therapeutic and/or prophylactic treatment for diabetes, obesity and related conditions).

  本申请涉及含硒的组合物（例如，富硒酵母和从中获得或衍生的含硒化合物）及其用于治疗和抑制肥胖、糖尿病和相关疾病的方法。具体而言，本申请提供了含硒富集酵母的组合物（例如，含有2％或更少无机硒的富硒酵母），其中含有或从中衍生的含硒化合物，并使用它们的方法来增强线粒体活性和功能（例如，在骨骼肌和肝脏中）以治疗和/或预防糖尿病、肥胖和相关疾病。
• [EN] COMPOSITIONS OF SELENOORGANIC COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSITIONS DE COMPOSÉS SÉLÉNOORGANIQUES ET LEURS PROCÉDÉS D'UTILISATION CORRESPONDANTS
  申请人：ALLTECH INC

  公开号：WO2015137983A1

  公开（公告）日：2015-09-17

  The present application relates to compositions comprising selenium compounds, such as 5'-Methylselenoadenosine, Se-Adenosyl-L -homocysteine, Gamma- glutamyl-methylseleno-cysteine, a compound of formula (I), formula (II), a compound of formula (III) and combinations thereof, and methods of using the same in enhancing mitochondrial function, or treating mitochondrial dysfunction.

  本申请涉及包含硒化合物的组合物，例如5'-甲基硒腺苷、Se-腺苷基-L-同型半胱氨酸、γ-谷氨酰-甲硒氨基酸、式（I）的化合物、式（II）的化合物、式（III）的化合物以及它们的组合物，并且使用这些化合物来增强线粒体功能或治疗线粒体功能障碍的方法。
• Compositions of selenoorganic compounds and methods of use thereof
  申请人：Alltech, Inc.

  公开号：US10201558B2

  公开（公告）日：2019-02-12

  The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, a compound of Formula (I), and combinations thereof, and methods of using the same for inhibiting β amyloid aggregation, ApoE4 expression, p38 or Tau protein phosphorylation, or increasing Neprilysin and Insulin Degrading Enzyme expression.

  本申请涉及包含硒化合物（如 5′-甲基硒腺苷、式（I）化合物及其组合）的组合物，以及使用该组合物抑制 β 淀粉样蛋白聚集、载脂蛋白 E4 表达、p38 或 Tau 蛋白磷酸化或增加肾蛋白酶和胰岛素降解酶表达的方法。
• COMPOSITIONS OF SELENOORGANIC COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Alltech, Inc.

  公开号：EP3144001B1

  公开（公告）日：2021-08-11
• COMPOSITIONS COMPRISING SELENIUM AND USE OF SAME FOR THE TREATMENT AND PREVENTION OF DISEASE OR CONDITIONS ASSOCIATED WITH MITOCHONDRIAL DYSFUNCTION
  申请人：POWER Ronan

  公开号：US20160113977A1

  公开（公告）日：2016-04-28

  The present application relates to compositions comprising selenium (e.g., selenium enriched yeast) and methods of using the same to treat and inhibit obesity, diabetes and related conditions. In particular, the present application provides compositions comprising selenium enriched yeast (e.g., selenium enriched yeast comprising 2% or less inorganic selenium), and methods of using the same to enhance mitochondrial activity and function (e.g., in skeletal muscle and liver) in a subject (e.g., as a therapeutic and/or prophylactic treatment for diabetes, obesity and related conditions).