8a-Methyl-1,2,3,5,6,8-hexahydroindolizin-7-imine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚里西啶
• 英文名称: 8a-Methyl-1,2,3,5,6,8-hexahydroindolizin-7-imine
• 英文别名: 8a-methyl-1,2,3,5,6,8-hexahydroindolizin-7-imine
• 化学式: C₉H₁₆N₂
• 分子量: 152.24
• InChiKey: IVVUYWHLLVEXMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  27.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• US20140275055A1
  申请人：——

  公开号：US20140275055A1

  公开（公告）日：2014-09-18
• Protein Kinase C Inhibitors and Uses Thereof
  申请人：Rigel Pharmaceuticals, Inc.

  公开号：US20170360786A1

  公开（公告）日：2017-12-21

  This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC. This disclosure also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
• US9169249B2
  申请人：——

  公开号：US9169249B2

  公开（公告）日：2015-10-27
• US9566278B2
  申请人：——

  公开号：US9566278B2

  公开（公告）日：2017-02-14