5-chloro-N-[(Z)-(3-phenyl-1,3-thiazolidin-2-ylidene)amino]thiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-chloro-N-[(Z)-(3-phenyl-1,3-thiazolidin-2-ylidene)amino]thiophene-2-carboxamide
• 化学式: C₁₄H₁₂ClN₃OS₂
• 分子量: 337.9
• InChiKey: MJKLOZYOPLTQFQ-VKAVYKQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  98.2
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INHIBITORS OF LRRK2 KINASE ACTIVITY
  申请人：ELAN PHARMACEUTICALS, LLC.

  公开号：US20160024071A1

  公开（公告）日：2016-01-28

  The present invention provides compounds having a structure according to Formula I. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

  本发明提供了具有I式结构的化合物。本发明还提供了包括本发明化合物的制药组合物以及使用本发明化合物和组合物的方法，例如在治疗和预防各种疾病，例如帕金森病。
• EP2968995A1
  申请人：——

  公开号：EP2968995A1

  公开（公告）日：2016-01-20
• [EN] INHIBITORS OF LRRK2 KINASE ACTIVITY<br/>[FR] INHIBITEURS DE L'ACTIVITÉ KINASE LRRK2
  申请人：ELAN PHARMACEUTICALS LLC

  公开号：WO2014150981A1

  公开（公告）日：2014-09-25

  The present invention provides compounds having a structure according to Formula I. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.